Changes

Leucocyte numbers can change rapidly. Patterns of change can help to determine the underlying cause.

Leucocyte numbers can change rapidly. Patterns of change can help to determine the underlying cause.

 

== Adrenaline mediated leucocytosis ==

== Adrenaline mediated leucocytosis ==

This is a transient, physiological change caused by the release of adrenaline,leading to the rapid shift of cells from the marginating pool into the circulating pool. This is most often seen in young excitable cats. There is leucocytosis with neutrophilia, often with lymphocytosis.

This is a transient, physiological change caused by the release of adrenaline,leading to the rapid shift of cells from the marginating pool into the circulating pool. This is most often seen in young excitable cats. There is leucocytosis with neutrophilia, often with lymphocytosis.

== Neutrophilia ==

== Neutrophilia ==

Initially an acute inflammatory stimulus, mediated through cytokines, causes release of the storage pool of mature neutrophils from the bone marrow. If the stimulus persists band neutrophils, metamyelocytes and occasionally myelocytes and promyelocytes are released from the bone marrow granulocyte pool. This is evident in the peripheral circulation a left shift.

Initially an acute inflammatory stimulus, mediated through cytokines, causes release of the storage pool of mature neutrophils from the bone marrow. If the stimulus persists band neutrophils, metamyelocytes and occasionally myelocytes and promyelocytes are released from the bone marrow granulocyte pool. This is evident in the peripheral circulation a left shift.

[[File:NWLLabfacts 30.jpg|thumb|Left Shift NationWide Laboratories]]

[[File:NWLLabfacts 30.jpg|thumb|'''Left Shift''' ©NationWide Laboratories 2017 ]]

A left shift of >1.0 x109/l band cells is diagnostic for inflammatory disease. Milder left shifts (0.3-1.0 x109/l bands) may occur with haemorrhage, chronic or granulomatous inflammation.  

A left shift of >1.0 x109/l band cells is diagnostic for inflammatory disease. Milder left shifts (0.3-1.0 x109/l bands) may occur with haemorrhage, chronic or granulomatous inflammation.  

== Authors & References ==

== Authors & References ==

[[NationWide Laboratories#In Partnership with NationWide Laboratories]]

[[NationWide Laboratories]]

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