Changes

==Introduction==

==Introduction==

The glomerular filtration rate or GFR is the amount of fluid filtered from the capillaries into the Bowmans capsule per unit time.  The GFR can be expressed as the following formula:

The glomerular filtration rate or GFR is the amount of fluid filtered from the capillaries into the Bowmans capsule of the kidneys per unit time.  The GFR can be expressed as the following formula:

<center><big>'''GFR = K_f x net filtration pressure'''</big></center>

<center><big>'''GFR = K_f x net filtration pressure'''</big></center>

'''The Limitations of Autoregulation'''

'''The Limitations of Autoregulation'''

Despite the efforts of the autoregulatory system an increase in blood pressure still leads to an increased secretion of salt and water.  This is because even a small percentage change in GFR leads to large percentage change in the excretion of salt and water.  This excretion is however far less drastic than would be the case without autoregulation and actually helps to restore pressure to normal.  This increase in urinary output as a result of an increase in arterial blood pressure is termed [[Kidney - Blood Pressure - Anatomy & Physiology#Pressure Diuresis|pressure diuresis]].

Despite the efforts of the autoregulatory system an increase in blood pressure still leads to an increased secretion of salt and water.  This is because even a small percentage change in GFR leads to large percentage change in the excretion of salt and water.  This excretion is however far less drastic than would be the case without autoregulation and actually helps to restore pressure to normal.  This increase in urinary output as a result of an increase in arterial blood pressure is termed [[Kidney Control of Blood Pressure - Anatomy & Physiology#Pressure Diuresis|pressure diuresis]].

===[[Renin Angiotensin Aldosterone System|Angiotensin 2]]===

===[[Renin Angiotensin Aldosterone System|Angiotensin 2]]===

 

[[Category:Urinary System - Anatomy & Physiology]]

[[Category:Urine Production]]