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Spleen - Anatomy & Physiology (view source)
Revision as of 14:15, 9 January 2023
, 14:15, 9 January 2023no edit summary
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|colspan="2"|<center><sup>©Nottingham Uni 2008</sup></center>
|colspan="2"|<center><sup>©Nottingham Uni 2008</sup></center>
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|colspan="2"|<center>[[Image:LH Spleen Gross Histology.jpg|200px]]</center>
|colspan="2"|<center>[[Image:LH Spleen Histology.jpg|200px]]</center>
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|colspan="2"|<center>'''Gross histological view'''</center>
|colspan="2"|<center>'''Histological view'''</center>
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|colspan="2"|<center><sup>©Nottingham Uni 2008</sup></center>
|colspan="2"|<center><sup>©Nottingham Uni 2008</sup></center>
Innervation is purely sympathetic<ref>{{citation|initiallast = Nance|initialfirst = D.M|finallast = Sanders|finalfirst = V.M|year = 2007|jtitle = Autonomic innervation and regulation of the immune system (1987-2007)|jor = Brain, Behavior, and Immunity|vol = 21(6)|range = 736-745}}</ref> and nerve fibres travel with the artery into the spleen.
Innervation is purely sympathetic<ref>{{citation|initiallast = Nance|initialfirst = D.M|finallast = Sanders|finalfirst = V.M|year = 2007|jtitle = Autonomic innervation and regulation of the immune system (1987-2007)|jor = Brain, Behavior, and Immunity|vol = 21(6)|range = 736-745}}</ref> and nerve fibres travel with the artery into the spleen.
===Histology===
===Histology===
<gallery perrow="3">
<center><gallery>
Image:LH_Spleen_Rat_Histology.jpg|<p>'''Gross view (rat)'''</p><sup>©RVC 2008</sup>
Image:LH_Spleen_Rat_Histology.jpg|<p>'''Low magnification view (rat)'''</p><sup>©RVC 2008</sup>
Image:LH_Spleen_Rat_Higher_Histology.jpg|<p>'''Red & white Pulp (rat) '''</p><sup>©RVC 2008</sup>
Image:LH_Spleen_Rat_Higher_Histology.jpg|<p>'''Red & white Pulp (rat) '''</p><sup>©RVC 2008</sup>
Image:LH_Spleen_Rat_Higher_2_Histology.jpg|<p>'''Central artery & PALS (rat) '''</p><sup>©RVC 2008</sup>
Image:LH_Spleen_Rat_Higher_2_Histology.jpg|<p>'''Central artery & PALS (rat) '''</p><sup>©RVC 2008</sup>
Image:LH_Spleen_Rat_Higher_3_Histology.jpg|<p>'''Trabecula and capsule (rat) '''</p><sup>©RVC 2008</sup>
Image:LH_Spleen_Rat_Higher_3_Histology.jpg|<p>'''Trabecula and capsule (rat) '''</p><sup>©RVC 2008</sup>
Image:LH_Spleen_Rat_Higher_4_Histology.jpg|<p>'''Trabeculae & erythrocytes (rat)'''</p><sup>©RVC 2008</sup>
Image:LH_Spleen_Rat_Higher_4_Histology.jpg|<p>'''Trabeculae & erythrocytes (rat)'''</p><sup>©RVC 2008</sup>
Image:LH_Spleen_Mouse_Higher_Histology.jpg|<p>'''Megakaryocyte & macrophages (mouse)'''</p><sup>©RVC 2008</sup></gallery>
Image:LH_Spleen_Mouse_Higher_Histology.jpg|<p>'''Megakaryocyte & macrophages (mouse)'''</p><sup>©RVC 2008</sup></gallery></center>
==Functions==
==Functions==
<p>Blood flows through the marginal sinus. This means that most antigens present in the blood come into contact with the [[Lymphocytes#B cells|B lymphocytes]] and dendritic cells in the spleen. Dendritic cells in the marginal sinus and red pulp take up antigens from the blood and transport them to the primary follicles in the white pulp. If the antigen activates the [[Lymphocytes#B cells|B lymphocytes]] then a germinal centre will form in the primary follicle and this is called a splenic nodule. Antibody producing cells then migrate to the red pulp and marginal zone.</p>
<p>Blood flows through the marginal sinus. This means that most antigens present in the blood come into contact with the [[Lymphocytes#B cells|B lymphocytes]] and dendritic cells in the spleen. Dendritic cells in the marginal sinus and red pulp take up antigens from the blood and transport them to the primary follicles in the white pulp. If the antigen activates the [[Lymphocytes#B cells|B lymphocytes]] then a germinal centre will form in the primary follicle and this is called a splenic nodule. Antibody producing cells then migrate to the red pulp and marginal zone.</p>
<p>Following splenectomy this doesn’t occur and animals are predisposed to septicaemia and infection with blood [[Protozoa|protozoa]].</p>
<p>Following splenectomy this doesn’t occur and animals are predisposed to septicaemia and infection with blood [[Protozoa|protozoa]].</p>
{{Template:Learning
|videos = [[Video: Equine thoracic cavity dissection|Equine thoracic cavity dissection]]<br>[[Video: Feline Abdomen|Feline Abdomen]]<br>[[Video: Foal gastrointestinal tract potcast|Foal gastrointestinal tract potcast]]<br>[[Video: Ruminant abdomen potcast|Ruminant abdomen potcast]]<br>[[Video: Lateral view of the feline thorax and abdomen potcast|Video: Lateral view of the feline thorax and abdomen potcast]]<br>[[Video: Abdominal viscera of the horse dissection|Abdominal viscera of the horse dissection]]
|OVAM = [http://www.onlineveterinaryanatomy.net/content/spleen-histology-low-power Spleen Histology - Low Power 1]<br>[http://www.onlineveterinaryanatomy.net/content/spleen-histology-low-power-0 Spleen Histology - Low Power 2]<br>[http://www.onlineveterinaryanatomy.net/content/spleen-histology-high-power Spleen Histology - High Power]<br>[http://www.onlineveterinaryanatomy.net/content/rodent-spleen-histology-0 Rodent Spleen Histology]
}}
{{Chapter}}
{{Mansonchapter
|chapterlink = http://www.mansonpublishing.co.uk/book-images/9781893441958_sample.pdf
|chaptername = Spleen histology
|book = Quick Look Series - Histology
|author = Jo Ann Eurell
|isbn = 9781893441958
}}
==In pathology==
==In pathology==
<br><br>
<br><br>
{{Jim Bee 2007}}
{{Jim Bee 2007}}
==Webinars==
<rss max="10" highlight="none">https://www.thewebinarvet.com/gastroenterology-and-nutrition/webinars/feed</rss>
[[Category:Spleen]]
[[Category:Spleen]]