Difference between revisions of "Complement Associated Diseases"
Jump to navigation
Jump to search
m (Text replace - "Category:To Do - Blood" to "Category:To Do - BloodCategory:To Do - Clinical") |
|||
(3 intermediate revisions by 2 users not shown) | |||
Line 1: | Line 1: | ||
− | + | <big><center>[[General Pathology|'''BACK TO GENERAL PATHOLOGY''']]</center></big> | |
− | For a description of the system and its functions see [[Complement]] | + | <br> |
+ | ==Complement System== | ||
+ | For a description of the system and its functions see [[Complement - WikiBlood|here]] | ||
==Complement Associated Diseases== | ==Complement Associated Diseases== | ||
* Most diseases associated with complement are linked to deficiencies of certain components. | * Most diseases associated with complement are linked to deficiencies of certain components. | ||
Line 22: | Line 24: | ||
**** C2 kinin is a potent inducer of inflammation and of vasodilatation. | **** C2 kinin is a potent inducer of inflammation and of vasodilatation. | ||
***** Results in hereditary angiodaema. | ***** Results in hereditary angiodaema. | ||
− | + | <br> | |
− | [[ | + | <big><center>[[General Pathology|'''BACK TO GENERAL PATHOLOGY''']]</center></big> |
− | |||
− |
Revision as of 21:26, 20 August 2008
Complement System
For a description of the system and its functions see here
Complement Associated Diseases
- Most diseases associated with complement are linked to deficiencies of certain components.
- Some deficiencies give inefficient removal of immune complexes, resulting in autoimmune disease.
- E.g. deficiencies in C1, C2, C4 and DAF.
- Immune complexes lodge ing the small capillary beds and induce inflammation.
- Results in, for example, glomerulonephritis, vasculitis, rheumatoid arthritis and inflammation/ irritation of the skin.
- E.g. Systemic Lupus Erythematosis.
- Deficiencies may also result in chronic infection.
- E.g. deficiences in C3, Factor B and Factors H and I.
- Factors H and I are inhibitors.
- Lack of thrse results in exhaustion of the C3 supply, causing a functional C3 deficiency.
- Factors H and I are inhibitors.
- Opsonisation and the lytic pathway do not function optimally without C3.
- E.g. deficiences in C3, Factor B and Factors H and I.
- Other deficiencies.
- C6
- Results in very few effects other that the inability to eliminate encapsulated bacterial infections.
- C1 esterase inhibitor.
- A rare genetic deficiency.
- C1 esterase inhibitor is an enzyme which controls the functioning of C1 esterase.
- Lack of this enzyme causes inappropriate activation of C2 and production of large quantities of C2a (also known as C2 kinin).
- C2 kinin is a potent inducer of inflammation and of vasodilatation.
- Results in hereditary angiodaema.
- C2 kinin is a potent inducer of inflammation and of vasodilatation.
- C6