Difference between revisions of "Type II Hypersensitivity"

Revision as of 13:55, 26 August 2008

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Type II Hypersensitivity-Brian Catchpole RVC 2008

Production of IgM or IgG to cell surface antigens or extracellular matrix proteins.

"Neutralisation" blockade of receptors:

Myasthenia gravis

Immunological attack on target cells, destroying them by:

1. Antibody dependent cell cytotoxicity (ADCC)

Pemphigus vulgaris
Bullous pemphigoid

2. Complement mediated lysis

Self RBC antigen:
- Immune mediated haemolytic anaemia
Foreign RBC:
- Blood transfusion reaction
- Haemolytic disease of new born (Rhesus disease in humans and neonatal isoerythrolysis in foals and kittens)
RBC parasite:
- Feline infectious anaemia (Mycoplasma haemofelis)

3. Phagocytosis

@@ Line 1: / Line 1: @@
-==Introduction==
+big><center>[[Hypersensitivity - WikiBlood|'''BACK TO Hypersensitivity''']]</center></big>
+----
 [[Image:Type II Hypersensitivity.jpg|right|thumb|150px|Type II Hypersensitivity-Brian Catchpole RVC 2008]]
-Production of [[Immunoglobulin M|IgM]] or [[Immunoglobulin G|IgG]] to cell surface antigens or extracellular matrix proteins.
+Production of IgM or IgG to cell surface antigens or extracellular matrix proteins.
-==Mechanism==
 ''' "Neutralisation" blockade of receptors:'''
-* Antibodies attach to receptors, which prevents other molecules attaching.
+* Myasthenia gravis
-* For example in myasthenia gravis antibodies attach to acetylcholine receptors which in turn prevents acetylcholine from attaching to the receptor and thus muscle contraction of that cell does not occur.
-''' Immunological attack on target cells, destroying them by (see diagram):'''
+''' Immunological attack on target cells, destroying them by:'''
-[[Adaptive Immunity to Viruses|1. Antibody dependent cell cytotoxicity (ADCC)]]
+. Antibody dependent cell cytotoxicity (ADCC)
-* [[Pemphigus|Pemphigus vulgaris]]
+* Pemphigus vulgaris
-* [[Bullous Pemphigoid|Bullous pemphigoid]]
+* Bullous pemphigoid
-. [[Complement|Complement]] mediated lysis
+. Complement mediated lysis
-* Self [[Erythrocytes|RBC]] antigen:
+* Self RBC antigen:
-** [[Immune Mediated Haemolytic Anaemia|Immune mediated haemolytic anaemia]]
+** Immune mediated haemolytic anaemia
-* Foreign [[Erythrocytes|RBC]]:
+* Foreign RBC:
 ** Blood transfusion reaction
-** [[Neonatal Isoerythrolysis|Haemolytic disease of new born (Rhesus disease in humans and neonatal isoerythrolysis in foals and kittens)]]
+** Haemolytic disease of new born (Rhesus disease in humans and neonatal isoerythrolysis in foals and kittens)
 * RBC parasite:
 ** Feline infectious anaemia (''Mycoplasma haemofelis'')
 . Phagocytosis
-==From Pathology==
-*Cytotoxic reaction
-*[[IgG]] and [[IgM]] interaction with antigens bound to cellular membranes
-*Often involves [[Complement#Complement Fixation Pathways|complement fixation]] -> cellular damage
-*In skin - circulating antibody to proteins of desmosomes in intercellular areas along basement membranes at epidermal-dermal junction
-*Includes:
-**[[Pemphigus|Pemphigus]]
-**[[Bullous Pemphigoid|Bullous pemphigoid]]
-<br><br>
-{{Jim Bee 2007}}
-[[Category:Hypersensitivity]]

Difference between revisions of "Type II Hypersensitivity"

Revision as of 13:55, 26 August 2008

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