Changes

*In cats, amyloidosis is sometimes present in the islets

*In cats, amyloidosis is sometimes present in the islets

*Fatty change is consistently present in the liver and kidneys

*Fatty change is consistently present in the liver and kidneys

*The lens in the eye is often opaque due to deposition of sorbitol causing it to swell (glucose is converted into sorbitol once the glycolytic pathway is saturated)

*The lens in the eye of the dog is often opaque due to deposition of sorbitol and fructose causing it to swell as the are not freely permeable (glucose is converted into sorbitol and fructose once the glycolytic pathway is saturated)

*In immune-mediated isletitis - progressive lymphoplasmacytic infiltration and selective destruction of islet cells

*In immune-mediated isletitis - progressive lymphoplasmacytic infiltration and selective destruction of islet cells

*Possible vacuolation of islet cells and epithelium of small ducts

*Possible vacuolation of islet cells and epithelium of small ducts