Difference between revisions of "Muscle Development - Anatomy & Physiology"

From WikiVet English
Jump to navigation Jump to search
(17 intermediate revisions by 6 users not shown)
Line 1: Line 1:
−
{{OpenPagesTop}}
+
<big><center>[[Developmental Biology - Anatomy & Physiology|'''BACK TO DEVELOPMENTAL BIOLOGY]]</center></big>
 +
 
 
==Introduction==
 
==Introduction==
−
[[Image:skeletal thigh muscle.png|right|thumb|250px|Lord of Konrad 2009 Cross of thigh muscle from a rat.]]
 
−
[[Muscles - Anatomy & Physiology|Muscle]] cells can come from two lineages in the [[Somite Development - Anatomy & Physiology|somite]]. '''Limb and body muscle''' develop from '''hypaxial muscle''' in the lateral regions of the somite. '''Back muscle''' develops from '''epaxial muscle''' in the dorsal regions of the somite. Muscle fibres have hundreds of nuclei and function as a syncytium.
 
−
 
−
==Muscle Cell Differentiation==
 
  
−
'''Precursor''' mesenchymal cells migrate from the dermomyotome. They divide rapidly en route and are undifferentiated. The cells with muscle gene expression differentiate to form '''myoblasts''', they are still mesenchymal cells, but can no longer migrate as they are differentiated. The '''myotube''' is formed and cells become multi - nucleated to form a syncytium. Muscle enzymes and the '''myofibre''' is produced. Contractile proteins are present.
+
Muscle cells can come from two lineages in the somite. Limb and body muscle develop from hypaxial muscle in the lateral regions of the somite. Back muscle develops from epaxial muscle in the dorsal regions of the somite. Muscle fibres have hundreds of nuclei and function as a syncytium.
  
−
==Limb Muscle Development==
 
  
−
[[Muscles - Anatomy & Physiology#Skeletal Muscle|Skeletal muscle]] of the limbs originates from those [[Somite Development - Anatomy & Physiology|somites]] closest to the limbs. Signalling factors from the limbs cause cells to migrate from the somite and causes the hypaxial lamina to break down, allowing cells to migrate. Few cells migrate but they rapidly proliferate during migration to increase cell numbers. Muscle precursors migrate into the [[Limb Development - Anatomy & Physiology|limb bud]] (proliferating). At the proximal region of the limb, two populations of cells exists, these are the dorsal and ventral masses. Cells continue migration within these populations. Once cells have reached their destinations, they differentiate.
+
==Muscle Development==
  
−
{{OpenPages}}
+
#'''Prescursor''' cells migrate from the dermomyotome.
−
[[Category:Developmental Biology]][[Category:Musculoskeletal System - Anatomy & Physiology]]
+
#*They are mesenchymal
−
[[Category:A&P Done]]
+
#*Divide rapidly en route and are undifferentiated.
 +
#Cells differentiate to form '''myoblasts'''.
 +
#*Cells still mesenchymal but can no longer migrate as differentiated.
 +
#*Muscle gene expression.
 +
#The '''myotube''' is formed; cells become multi - nucleated to form a syncytium.
 +
#*Muscle enzymes are produced.
 +
#The '''myofibre''' is produced.
 +
#*Contractile proteins are present.

Revision as of 08:29, 31 August 2008

BACK TO DEVELOPMENTAL BIOLOGY

Introduction

Muscle cells can come from two lineages in the somite. Limb and body muscle develop from hypaxial muscle in the lateral regions of the somite. Back muscle develops from epaxial muscle in the dorsal regions of the somite. Muscle fibres have hundreds of nuclei and function as a syncytium.


Muscle Development

  1. Prescursor cells migrate from the dermomyotome.
    • They are mesenchymal
    • Divide rapidly en route and are undifferentiated.
  2. Cells differentiate to form myoblasts.
    • Cells still mesenchymal but can no longer migrate as differentiated.
    • Muscle gene expression.
  3. The myotube is formed; cells become multi - nucleated to form a syncytium.
    • Muscle enzymes are produced.
  4. The myofibre is produced.
    • Contractile proteins are present.
Retrieved from "https://en.wikivet.net/index.php?title=Muscle_Development_-_Anatomy_%26_Physiology&oldid=32783"