Changes

'''Advantages'''

'''Advantages'''

*Long duration of action as once antibody is produced against the antigen, memory cells are formed which continue circulating in the body

*Long duration of action  

**Once antibody is produced against the antigen, memory cells are formed which continue circulating in the body

**For further information on memory cells click [[B cell differentiation - WikiBlood|here]]

**For further information on memory cells click [[B cell differentiation - WikiBlood|here]]

'''Disadvantages'''

'''Disadvantages'''

*Delay in protection as the host's immune system needs to evoke an immune response against the antigen

*Delay in protection  

**The host's immune system needs to evoke an immune response against the antigen which can take a few days

**For further information on the antibody response click [[Adaptive Immune System - WikiBlood|here]]

**For further information on the antibody response click [[Adaptive Immune System - WikiBlood|here]]

*Often needs two or more doses as the first dose initiates the '''priming''' reaction where antibody production ceases after a few weeks, but the second and subsequent doses creates memory cells which remain in the circulation for a much longer period of time

*Often needs two or more doses  

**The first dose initiates the '''priming''' reaction where antibody production ceases after a few weeks, but the second and subsequent doses creates memory cells which remain in the circulation for a much longer period of time

**For further information on the T cell independent and dependent responses click [[B cell differentiation - WikiBlood#T-Cell Dependent and Independent Responses|here]]

**For further information on the T cell independent and dependent responses click [[B cell differentiation - WikiBlood#T-Cell Dependent and Independent Responses|here]]