Difference between revisions of "Consequences of Gastric Disease - Pathology"

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Revision as of 14:00, 26 September 2008


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()Map ALIMENTARY SYSTEM (Map)
STOMACH AND ABOMASUM



Vomiting

  • Has potentially lethal effects in the monogastric animal.


Water Loss

  • Fluid loss is evident as:
    1. An increased PCV or haematocrit.
    2. An increased total protein concentration.
    3. A prerenal azotaemia.


Gastric Electrolyte Loss

  • The main losses are of H+ and Cl-, and also K+
  • Can potentially cause metabolic alkalosis, although this is only likely with disease which stops at the pylorus, e.g.: pyloric outflow obstruction.
    • In cases where mild alkalosis occurs, homeostatic mechanisms produce a more alkaline urine to restore normal body pH.
    • However, in severe metablolic alkalosis with marked dehydration, acidic urine may be produced- this is termed paradoxical aciduria.
      • Because vomiting induceses hypokalaemia, there is an overriding stimulus in the kidney for Na+ (and therefore water) retention.
      • Na+ can only be resorbed in exchange for H+
        • H+ is therefore excreted in the urine, causing it to be acidic.
      • Vomiting also induces hypochloraemia, meaning bicarbonate rather than chloride is resorbed with the Na+ to maintain electrical neutrality
        • This perpetuates the alkalosis.
  • Vomiting does not occur in the ruminant although abomasal content may reflux into the forestomachs.
    • Sequestration of secretions in the abomasum will have similar effects to pyloric outflow obstruction with vomiting in the monogastric animal.
      • e.g. abomasal torsion
      • Causes dehydration, hypochloraemia, hypokalaemia and metabolic alkalosis.


  • Lesions in the small intestine can also lead to vomiting
    • Both gastric acid and pancreatic and intestinal bicarbonate secretions are lost
      • Animal consequently has a normal pH or may even be acidotic.

Raised Intraluminal pH

  • Associated with some forms of gastritis.
    • e.g. Ostertagiasis
  • Causes failure of digestion.
    • Anorexia and weight loss follow.
  • Increases the number of bacteria in the stomach.
  • Diarrhoea reults
    • Cause is unknwn is unknown but appears to be related to the elevated pH.

Hyperacidity

  • May develop in certain gastric disturbances
  • Thought to be a contributory factor in peptic ulceration.

Anaemia

  • May also develop in certain gastric diseases
  • Is usually haemorrhagic in nature
    • Due to bleeding from gastric ulceration.