Changes

*Infected cats develop antibody whether or not they are able to clear the virus

*Infected cats develop antibody whether or not they are able to clear the virus

Two versions:

Two versions:

*Avirulent:

*'''Avirulent''':

**Transient infection with no CD4 decline

**Transient infection with no CD4 decline

*Virulent:

*'''Virulent''':

**Progressive CD4 decline with three stages (may present indistinct)

**Progressive CD4 decline with three stages (may present indistinct)

**#'''High circulating virus''' for 1-10 weeks with resulting lymphoid depletion and CD8CD4 double positive Tcell destruction, '''thymic aplasia''' esp in kittens

**#'''High circulating virus''' for 1-10 weeks with resulting lymphoid depletion and CD8CD4 double positive Tcell destruction, '''thymic aplasia''' esp in kittens

**#'''Remission''': decrease in circulating virus as immune response increases, followed by '''immune exhaustion'''

**#'''Remission''': decrease in circulating virus as immune response increases, followed by '''immune exhaustion'''

****Increase in CD8+ production and antibody response

**#*Increase in CD8+ production and antibody response

****Paracortical T cells and lymphoid follicles expand in primary and secondary lymph tissue and may be visible as '''white nodules'''

**#*Paracortical T cells and lymphoid follicles expand in primary and secondary lymph tissue and may be visible as '''white nodules'''

**#'''Rapidly progressing infection''' with high virus present  

**#'''Rapidly progressing infection''' with high virus present  

****Feline AIDS presents in a minority of cases

**#*Feline AIDS presents in a minority of cases

****Nonregenerative anemia

**#*Nonregenerative anemia

****Leucopenia

**#*Leucopenia

****Neutropenia

**#*Neutropenia

****Usually followed by secondary infection as a result of '''immunosuppression'''

**#*Usually followed by secondary infection as a result of '''immunosuppression'''

****Virus-ridden T cell destroy normal T cells, causing chronic immunosuppression

**#*Virus-ridden T cell destroy normal T cells, causing chronic immunosuppression

====Epidemiology====

====Epidemiology====