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→Spectrum of Activity
==Spectrum of Activity==
==Spectrum of Activity==
* Active against gram-negative species including aerobic species such as ''Pseudomonas aeruginosa''.
* Active against gram-positives (doesn't work that well against Streptococcal species and enterococci.)
* Works well against Mycoplasmas and Rickettsia.
* Poor activity against obligate anaerobes.
* Their activity is very pH dependent wit their activity increasing above pH 7.4 and decreasing below pH 7.0.
It should be noted that they are active at very low concentrations, they don't kill protective enterococci and anaerobes, and they will inhibit aminoglycoside and beta-lactam resistant bacteria.
==Pharmacokinetic Considerations==
==Pharmacokinetic Considerations==