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→Pharmacokinetic Considerations
==Pharmacokinetic Considerations==
==Pharmacokinetic Considerations==
Chloramphenicol and analogues: Highly lipophilic neutral small molecules.
• Orally active.
• Very wide volume of distribution – penetrates across cell membranes readily – the data shown on the slide are for penetration into bronchial secretions.
Bronchial fluid is a transcellular fluid – what are the barriers for a drug to diffuse into this fluid?
• Hepatic metabolism (varies between species and with age) for chloramphenicol.
• A higher proportion of the administered dose of thiamphenicol and florphenicol are excreted unchanged in the urine.
==Side Effects and Contraindications==
==Side Effects and Contraindications==
==Florfenicol and Thiamphenicol==
==Florfenicol and Thiamphenicol==