Pharmacokinetics for NSAIDs differ greatly between species, meaning that data from one species cannot be used to reliably calculate a dose for another. An example of such a variation is provided by phenylbutazone, which has zero-order kinetics in some species (including the dog), but first order kinetics in others. This means the half-life of this drug is variable and unpredictable.
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NSAIDs may be administered orally or parentally. As they are weak acids, NSAIDs are well absorbed following oral administration. The presence of food may, however, interfere with this absorption.
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Non-steroidal anti-inflammatory drugs have a high degree of plasma protein binding (approaching 99%). This means that other highly plasma protein-bound drugs with stronger binding affinities may displace NSAIDs from their binding. This would lead to an increase in circulating free drug levels and hence potential overdose. Although this is a theoretical risk, it has been demonstrated in relation to warfarin administration.