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→Causes of Fatty Change
====Causes of Fatty Change====
====Causes of Fatty Change====
=====Dietary and Metabolic=====
a. Starvation - this is an increased mobilisation of fat from the body fat stores in response to
a. Starvation - this is an increased mobilisation of fat from the body fat stores in response to
energy needs occasioned by a reduction in dietary intake. These are transported in the blood
energy needs occasioned by a reduction in dietary intake. These are transported in the blood
Some poisons e.g. CCl4, phosphorus and alcohol also prevent stages leading to the
Some poisons e.g. CCl4, phosphorus and alcohol also prevent stages leading to the
formations of lipoproteins.
formations of lipoproteins.
=====Metabolic diseases=====
- those accompanying a deranged carbohydrate metabolism in which
glucose is not made available for uptake into the tissues. Alternative pathways are resorted to
glucose is not made available for uptake into the tissues. Alternative pathways are resorted to
for the production of energy needed by the cells, and this leads to fatty change.
for the production of energy needed by the cells, and this leads to fatty change.
in the milk of high-yielding dairy cows shortly after parturition (Acetonemia), exhorts the
in the milk of high-yielding dairy cows shortly after parturition (Acetonemia), exhorts the
body to find another source of energy, with consequent mobilisation of fat reserves and their
body to find another source of energy, with consequent mobilisation of fat reserves and their
transportation to the liver.
transportation to the liver
=====Anoxia=====
- an inadequate supply of oxygen to the tissues
Any condition that reduces the oxygen supply to the tissues will cause fatty change in the
Any condition that reduces the oxygen supply to the tissues will cause fatty change in the
liver. Anaemia ( a reduced numbers of red blood cells circulating in the blood ) caused by
liver. Anaemia ( a reduced numbers of red blood cells circulating in the blood ) caused by
circulatory disorders such as ischaemia ( reduced blood supply to a tissue ) and chronic
circulatory disorders such as ischaemia ( reduced blood supply to a tissue ) and chronic
venous congestion ( slowing of blood flow through the vasculature ) due to a failing heart.
venous congestion ( slowing of blood flow through the vasculature ) due to a failing heart.
=====Toxins=====
. A large number of toxins will cause fatty change in the liver. In these cases,
consider the fatty change to be a more severe form of cellular swelling. Among these are;
consider the fatty change to be a more severe form of cellular swelling. Among these are;
a. bacterial and fungal toxins- either produced in the bloodstream from circulating bacteria
a. bacterial and fungal toxins- either produced in the bloodstream from circulating bacteria