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== Introduction ==
== Introduction ==
Laminits is a common and debilitating condition of horses. To revise the anatomy of the hoof see [[Equine Phalanges - Anatomy & Physiology]]
Laminits is a common and debilitating condition of horses cause by separation of the laminae of the hoof. It can be acute or chronic and can result in the horse being put down. To revise the anatomy of the hoof see [[Equine Phalanges - Anatomy & Physiology]]
== Etiology ==
== Etiology ==
Acute degeneration of the sensitive primary and secondary Laminae
Acute degeneration of the sensitive primary and secondary Laminae. The cause for this is unknown.
== Epidemiology==
=== Increased Risk Factors ===
* Obesity
* Access to lush pastures
* Grain overload (Ingestion of large quantities of soluble carbohydrates)
* Retained Placenta
* Colic and Diarrhoea
* Systemic Illness
* Animals having little exercise
* [[Pituitary Pars Intermedia Dysfunction / Equine Cushing's]]
* Trauma/excessive work on hard surfaces
* Increased weight bearing on one limb
== Pathogenesis ==
The separation of the sensitive laminae (originated from the third phalanx/pedal bone) from the laminae lining the inside surface of the hoof.
This allows the pedal bone to '''rotate''' within the hoof capsule and come to rest on the sole. This causes the sole to be pushed downwards and at the toe the pedal bone mat penetrate the sole.
Rotation occurs due to torque from the deep digital flexor tendon.
Also due to the weight of the animal the pedal bone can '''sink''' (displace ventrally). The bone may rotate, sink or both.
Serum accumulates in the space between the laminae and can breakdown the white line.
=== Mechanism of Separation of the Laminae ===
The mechanism is unknown but theories are:
* Ischaemia and necrosis. Ischaemia may be caused by:
** Vasoconsriction
** Arterio-venous shunts
** Interstitial Oedema
** A mixture of the above
* Inflammation and then degeneration of the sensitive laminae
* Enzymatic digestion of laminae by Matrix Metalloproteins (MMPs)
* Abnormalities in the hoof metabolism or corticosteriods (Endogenous cortisol or iatrogenic) which results in increased glucocorticoid activity.
Subsequent to separation of the laminae a '''pain-hypertension-vasoconstiction''' cycle will occur in acute cases
* Pain causes:
** Release of vasoconstictors (catecholamines, angiotensin II, vasopressin)
* Vasoconstriction causes a reduced blood flow to the foot and systemic hypertension.
== Clinical Signs ==
=== Acute Disease ===
* Develops Rapidly
* Most commonly in the front feet
* Mild or early disease can be seen as reluctance to move and frequent shifting of weight
* Characteristic gait
* If more severe the horse may be:
** Unwilling to move or pick up it's feet
** Show signs of pain (Anxiety, sweating, increased heart and respiration rate)
** Characteristic posture which looks like the horse is standing on its heels, all feet are placed forward of their normal position, the head is low and the back is arched
** Occasionally there may be serum like exudate at the coronary band and the hoof may become detached and shed. Although this indicated a very severe case with good and dedicated owners, vets and farriers who are prepared for the time and cost of treatment the horse can survive sloughing of the hoof and go back to normal work.
=== Chronic Disease ===
Separation of the laminae and sinking and/or rotation of the pedal bone have occurred. The sole has dropped. The hoof wall spreads which results in marked transverse ridges on the hoof. Also the angle of the hoof as viewed laterally decreases. Degeneration of the white line may allow for infection to enter. The pedal bone may become septic. The Animal may become lame with exercise and have repeated bouts of mild laminitis.
== Diagnosis ==
* Pain on palpation around the coronet
* Marked withdrawal in response to hoof testers
* Increased height and strength of pulse in the palmer digital artery
* If the pedal bone has sunk a concavity may be palpable at the junction of the coronet
=== Radiography ===
Radiographs should be taken of front feet or all feet if all legs are affected. A metal strip should be placed on the dorsal wall of the hoof and the sole should be maked with a similar metal strip or a pin can be used. They the angle of the pedal bone in relation to the hoof can then be analysed and the radiograph should be shown to the farrier who is working with you on the case for corrective farriery.
* If mild or acute may show no changes
* May show rotation of the pedal bone as a tilting of the distal aspect towards the sole
* Serum build up may be evident as a radiolucent line between the dorsal hoof wall and the pedal bone