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| + | #REDIRECT[[:Category:Coccidia]] |
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| − | {{toplink
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| − | |linkpage =Parasites
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| − | |linktext =PARASITES
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| − | |pagetype=Bugs
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| − | |sublink1=Protozoa
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| − | |subtext1=PROTOZOA
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| − | <br>
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| − | ==Introduction==
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| − | [[Image:Coccidia oocyst ruminant.jpg|thumb|right|150px|Coccidia oocyst from ruminant faeces - Joaquim Castellà Veterinary Parasitology Universitat Autònoma de Barcelona]]
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| − | [[Image:Eimeria.jpg|thumb|right|150px|''Eimeria'' - Joaquim Castellà Veterinary Parasitology Universitat Autònoma de Barcelona]]
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| − | [[Image:Isospora.jpg|thumb|right|150px|''Isospora'' - Joaquim Castellà Veterinary Parasitology Universitat Autònoma de Barcelona]]
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| − | Poultry coccidiosis is caused by ''Eimeria'' species. The poultry industry has grown to its massive size through the development and administration of anticoccidial drugs. Most growing birds are fed compounded rations containing anticoccidial drugs which has radically reduced the deaths from coccidiosis bringing the mortality rate down to negligable levels. Careful management is needed to prevent decreased productivity from infection through decreased egg production, weight gain and feed conversion ratios.
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| − | | |
| − | Mammalian coccidiosis is usually associated with watery [[Intestine Diarrhoea - Pathology|diarrhoea]], dysentry and weight loss. It usually presents in young animals which are living in overcrowded and unhygienic conditions.
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| − | | |
| − | Pathogenicity of coccidiosis is related to the size of the endogenous stages, the location of the infection in the mucosa and the site of infection. For example, infection in the small intestine can lead to compensation whereas infection in the large intestine will affect water absorption. If mucosal stem cells are affected, it will cause villous atrophy and a slow recovery.
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| − | | |
| − | ==''Eimeria'' spp.==
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| − | | |
| − | *Many species occur
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| − | *All species are host specific
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| − | | |
| − | *Sporulated oocyst has 4 sporocysts which each contain 2 sporozoites
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| − | **Oocyst measures 20-50μm
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| − | *Direct life cycle
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| − | *Transmission by the oral-faecal route
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| − | | |
| − | ==''Isospora'' spp.==
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| − | | |
| − | *Many species occur
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| − | | |
| − | *All species are host specific
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| − | | |
| − | *Sporulated oocyst conatins 2 sporocysts each with 4 sporozoites
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| − | **Oocyst measures 20-50μm
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| − | | |
| − | *Usually direct life cycle
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| − | **Transmission via the oral-faecal route
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| − | | |
| − | *Some species use facultative intermediate hosts and form tissue cysts
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| − | **Transmission via faecal-oral route or by ingestion of the intermediate host
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| − | | |
| − | ==Coccidia of Poultry==
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| − | [[Image:Buff orpington.jpg|thumb|right|150px|Buff orpington - nabrown RVC]]
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| − | [[Image:Eimeria Sporulated.jpg|thumb|right|150px|Sporulated ''Eimeria'' - Joaquim Castellà Veterinary Parasitology Universitat Autònoma de Barcelona]]
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| − | *Direct life cycle
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| − | *1 week prepatent period
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| − | | |
| − | *After oocysts are ingested, sporozoites are released which penetrate the intestinal epithelium
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| − | | |
| − | *2 asexual phases of multiplication called schizongony occur followed by a phases of sexual multiplication called gametogeny
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| − | | |
| − | *Zygote develops an oocyst which is shed in the faeces
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| − | **Oocyst measures 20-30μm
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| − | | |
| − | *For each oocyst ingested, thousands are shed
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| − | | |
| − | *Life cycle is '''self-limiting'''
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| − | **Organisms from a single infection go through the sequence of developmental stages synchronously
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| − | **Organisms leave the body simultaneously as oocysts
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| − | | |
| − | *Oocysts are only infective once they have sporulated
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| − | **Sporulation requires warmth, moisture and oxygen
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| − | **Takes 2-3 days in broiler houses
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| − | | |
| − | *Oocysts contain 4 sporocysts each with 2 sporozoites
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| − | | |
| − | '''Pathogenesis'''
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| − | *7 important ''Eimeria'' species
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| − | *4 malabsorptive species
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| − | **''Eimeria acervulina'' which is moderately pathogenic
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| − | **''Eimeria maxima'' which is moderately pathogenic
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| − | **''Eimeria mitis'' which has low pathogenicity
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| − | **''Eimeria praecox'' which has low pathogenicity
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| − | | |
| − | *3 haemorrhagic species
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| − | **''Eimeria tenella''
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| − | **''Eimeria necatrix''
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| − | **''Eimeria brunetti''
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| − | **All highly pathogenic
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| − | **Form large sub-epithelial second generation schizontsat the base of intestinal crypts
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| − | **Deep eruptions form when cells rupture to release merozoites
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| − | **Destruction of crypt stem cells and marked haemorrhage
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| − | **Blood stained faeces
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| − | **High morbidity and high mortality
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| − | | |
| − | '''Diagnosis'''
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| − | *Post-mortem diagnosis of lesion severity
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| − | **Region of intestine affected
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| − | **Appearance of lesion
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| − | **Presence or adsence of haemorrhage
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| − | **Size of schizonts and oocysts found in mucosal scrapings
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| − | *''Eimeria acervulina''
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| − | **Proximal gut
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| − | **Thickening of walls
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| − | **'White ladder lesions' produced by dense foci of gamonts and oocysts
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| − | **Watery exudate
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| − | *''Eimeria maxima''
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| − | **Mid-gut
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| − | **Thickening of walls
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| − | **Pink exudate
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| − | *''Eimeria tenella''
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| − | **Swollen [[Caecum - Anatomy & Physiology|caeca]]
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| − | **Thickening of wall
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| − | **Dark colouring containing a core of necrotic tissue and blood
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| − | | |
| − | *Lesion scoring is the best method of diagnosing the severity of the lesions and therefore the causative ''Eimeria'' species
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| − | *''Eimeria necatrix''
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| − | **Mid-gut
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| − | **Ballooning of wall
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| − | **White spots and petechiae forming 'salt and pepper' lesions
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| − | **Haemorrhage into lumen
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| − | | |
| − | '''Immunity'''
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| − | *Different ''Eimeria'' species produce different levels of protective immunity
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| − | **''E.maxima'' -> ''E.brunetti'' and ''E.acervulina'' -> ''E.tenella'' and ''E.necatrix''
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| − | | |
| − | *There is no cross immunity between species
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| − | | |
| − | *There is very little passive immunity
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| − | *Evokes a cell-mediated response
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| − | | |
| − | *All ages of poultry are susceptible
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| − | | |
| − | '''Epidemiology'''
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| − | *Oocysts are ubiquitous and robust
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| − | **Able to survive several months to years
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| − | | |
| − | *It is impossible to keep buildings free from infection
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| − | **Chicks become infected by pecking the ground shortly after being placed in the poultry house
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| − | | |
| − | *Biotic potential is enormous
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| − | **Generation time is short
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| − | **Massive infections can build up rapidly
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| − | | |
| − | *Immunity develops relatively slowly
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| − | **With high stocking densities the situation is explosive
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| − | '''Control'''
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| − | *Chemical
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| − | **Intensive poultry production is largely dependent on the use of anticoccidial drugs
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| − | **For more information see [[Anti-Protozoal Drugs|here]]
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| − | | |
| − | *[[Vaccines - WikiBlood|Vaccines]]
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| − | **Paracox
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| − | ***Multivalent attenuated [[Vaccines - WikiBlood#What antigen(s) do we use in the vaccine?|live vaccine]] for replcement layers and broilers
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| − | ***Contains 7 live strains of ''Eimeria''
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| − | ***Lack the most pathogenic life cycle stage making the prepatent period shorter
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| − | ***Known as '''precocious''' strains
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| − | ***Chicks [[Vaccines - WikiBlood|vaccinated]] on a single occasion when 1-9 days old through oocyst suspension in the feed or water
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| − | ***[[Vaccines - WikiBlood|Vaccinated]] birds have sub-optimal growth rates so is not used for broilers
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| − | **Paracox 5
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| − | ***Contains 5 strains of the most pathogenic ''Eimeria''
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| − | ***Used for broilers
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| − | ***Sprayed onto the first feed offered to new batches of chicks
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| − | | |
| − | *Integrated control
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| − | **Careful management is needed so in-feed prophylaxis and [[Vaccines - WikiBlood|vaccination]] do not fail
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| − | **Remove litter and thoroughly clean houses in between crops
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| − | ***Optimum turn-around time is 10 days
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| − | **Use the lowest stocking density which is compatible with economic production
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| − | **Water bowls, roofs and walls should be well maintained to prevent litter becoming damp
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| − | **Stress factors should be avoided and adequate nutrition provided
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| − | | |
| − | ==Other Avian Coccidia==
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| − | ===Coccidia of Turkeys===
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| − | | |
| − | *5 ''Eimeria'' species
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| − | **2 important pathogenically
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| − | *''Eimeria'' in [[Caecum - Anatomy & Physiology|caeca]] causes petechial haemorrhages and caseous [[Caecum - Anatomy & Physiology|caecal]] cores
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| − | *''Eimeria'' in the anterior and mid-intestine causes necrotic enteritis and petechial haemorrhages
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| − | | |
| − | *Causes watery [[Intestine Diarrhoea - Pathology|diarrhoea]] in young poults and some mortality
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| − | ===Coccidia of Geese===
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| − | *3 ''Eimeria'' species
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| − | *2 intestinal species causing macroscopic lesions in [[Urinary System - Anatomy & Physiology#The Kidney|kidney tubules]]
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| − | **Oocysts carried in urine and pass out with faeces
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| − | | |
| − | *Renal species cause severe disease in goslings
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| − | **Depression, emaciation, [[Intestine Diarrhoea - Pathology|diarrhoea]] and sometimes death
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| − | ===Coccidia of Ducks===
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| − | [[Image:Crested duck.jpg|thumb|right|150px|Crested duck - nabrown RVC]]
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| − | *Several ''Eimeria'' species
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| − | *Another coccidia species which produces 8 sporozoites which are not enclosed in a sporocyst
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| − | | |
| − | *Causes severe enteritis and mortality in ducklings
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| − | **Haemorrhages and pale focal lesions in [[Small Intestine - Anatomy & Physiology|small intestine]]
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| − | ===Coccidia of Game Birds===
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| − | *3 main species
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| − | *[[Caecum - Anatomy & Physiology|Caecal]] species most pathogenic causing white [[Caecum - Anatomy & Physiology|caecal]] cores
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| − | ==Coccidia of Cattle==
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| − | [[Image:Coccidia ruminant.jpg|thumb|right|150px|''Eimeria'' sp. of ruminants - Joaquim Castellà Veterinary Parasitology Universitat Autònoma de Barcelona]]
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| − | *Many species affect cattle
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| − | | |
| − | *Cattle under a year old are usually infected sporadically
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| − | | |
| − | *2-3 week prepatent period
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| − | *''Eimeria bovis''
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| − | **Endogenous stages in central lacteal of villi and epithelial cells of [[Caecum - Anatomy & Physiology|caecum]] and [[Colon - Anatomy & Physiology|colon]]
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| − | **Causes [[Intestine Diarrhoea - Pathology|diarrhoea]] and enteritis
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| − | **Oocysts are 28x20μm
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| − | **Moderately pathogenic
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| − | *''Eimeria zuernii''
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| − | **Endogenous stages in connective tissue of lamina propria of the lower [[Small Intestine - Anatomy & Physiology|small intestine]] and in the epithelial cells of the [[Caecum - Anatomy & Physiology|caecum]] and [[Colon - Anatomy & Physiology|colon]]
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| − | **More pathogenic than ''Eimeria bovis''
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| − | **Causes blood stained dysentry, tenesmus and sloughed mucosa
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| − | **Oocysts are spherical and measure 16μm
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| − | | |
| − | *Mainly occurs in calves in poor conditions and brought-in calves
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| − | **Also occurs in suckler calves turned out in spring
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| − | *''Eimeria alabamensis'' associated with [[Intestine Diarrhoea - Pathology|diarrhoea]] in calves after spring turnout
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| − | *[[Materno-fetal immunity - WikiBlood#Passive transfer via colostrum|Passive immunity]] is sufficient during the neonatal period
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| − | *Can be concurrent with cryptosporidium, viral and bacterial agents
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| − | '''Diagnosis'''
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| − | *History, clinical signs, [[Intestine Diarrhoea - Pathology|diarrhoea]] (often with blood) and a decrease in weight gain
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| − | *Post-mortem
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| − | **Diffuse inflammation and thickening of [[Caecum - Anatomy & Physiology|caecal]] mucosa (and sometimes [[Ileum - Anatomy & Physiology|ileal]] and [[Colon - Anatomy & Physiology|colonic]] mucosa)
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| − | **Masses of gamonts and oocysts in scrapings
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| − | *High faecal oocyst count
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| − | **However, healthy animals can pass millions of oocysts from mixed species infections which have no pathogenic significance
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| − | **Animals may die before oocysts are shed
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| − | '''Control'''
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| − | *Improve husbandry
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| − | **Improve sanitation
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| − | **Increase bedding
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| − | **Raise faecal and water troughs to avoid faecal contamination
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| − | *Preventative in-feed medication
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| − | **E.g. Decoquinate
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| − | *Injectible antiprotozoals may limit oocyst production but animals should still be moved to a clean environment
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| − | **E.g. Sulphamethoxypyridazine
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| − | ==Coccidia of Sheep==
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| − | *11 different Coccidia species although only two are of clinical significance
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| − | **Giant schizonts visible as white spots
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| − | *''Eimeria ovinoidalis''
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| − | **Highly pathogenic
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| − | **[[Intestine Diarrhoea - Pathology|Diarrhoea]]
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| − | **Parasitises the [[Caecum - Anatomy & Physiology|caecum]] and [[Colon - Anatomy & Physiology|colon]]
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| − | *''Eimeria crandalis''
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| − | **Varying pathogenicity
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| − | **Scours, grey, foul-smelling faeces
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| − | **Parasitises the [[Small Intestine - Anatomy & Physiology|small intestine]], [[Caecum - Anatomy & Physiology|caecum]] and [[Colon - Anatomy & Physiology|colon]]
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| − | *2 week prepatent period
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| − | *Disease frequently seen in lambs under 6 months old
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| − | **More often in twins and triplets when single lambs
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| − | *Oocyts from ewes (immune carriers) accumulate in poorly managed litter or around feed and water troughs
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| − | *Lambs born early in the year amplify the parasite problem increasing the parasite risk to lambs born later in the year
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| − | *Affected lambs may die before oocysts are found in the faeces
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| − | **Post-mortem diagnosis difficult
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| − | *Different species of ''Eimeria'' occurs in sheep and goats
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| − | *Infection may be coincident with ''Neospora'' or ''Cryptosporidium'' infections
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| − | **Mixed infections complicate the diagnosis as oocyst differentiation is difficult
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| − | *Other non-pathogenic species can cause papillomatous mucosal growths
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| − | '''Control'''
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| − | *Improve husbandry
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| − | **Avoid overcrowding
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| − | **Decrease stress
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| − | *Improve hygiene by dagging ewes
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| − | *Avoid mixing lambs of different ages
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| − | *Preventative measures include creep feeding lambs with decoquinate or oral dosing with diclazuril when lambs are 4-6 weeks
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| − | **A second dose can be given after 3 weeks
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| − | ==Coccidia of Goats==
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| − | [[Image:Goats.jpg|thumb|right|150px|Goats - nabrown RVC]]
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| − | [[Image:Eimeria leukarti horse.jpg|thumb|right|150px|''Eimeria leukarti'' - Joaquim Castellà Veterinary Parasitology Universitat Autònoma de Barcelona]]
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| − | *Many ''Eimeria'' species
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| − | *2 ''Eimeria'' are pathogenic
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| − | **Cause [[Intestine Diarrhoea - Pathology|diarrhoea]] and a decreased growth rate
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| − | *Different species of ''Eimeria'' occurs in sheep and goats
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| − | ==Coccidia of Horses==
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| − | *Only one atypical ''Eiemria''
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| − | *Forms large subepithelial gametocytes in villi
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| − | *Large, dark coloured oocysts
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| − | **Approximately 12μm
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| − | *Occasionally causes [[Intestine Diarrhoea - Pathology|diarrhoea]]
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| − | *''Besnoitia bennetti'' in [[Respiratory Parasitic Infections - Pathology#Besnoitia bennetti|larynx]] of horses
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| − | ==Coccidia of Pigs==
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| − | *Many species of ''Eimeria'' and ''Isospora''
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| − | *Only ''Isospora suis'' is of clinical pathogenic importance
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| − | *Causes sporadic, serious and sometimes fatal disease in unweaned piglets
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| − | **Causes profuse [[Intestine Diarrhoea - Pathology|diarrhoea]]
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| − | *Very short 1 week prepatent period
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| − | *[[Intestine Diarrhoea - Pathology|Diarrhoea]] starts before oocysts are shed in faeces
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| − | **Ante-mortem diagnosis is difficult
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| − | *Death usually occurs after parasites have left the host
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| − | **Post-mortem diagnosis difficult
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| − | **''Isospora'' infections are '''self-limiting'''
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| − | | |
| − | ==Coccidia of Dogs==
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| − | [[Image:Isospora canis.jpg|thumb|right|150px|''Isospora canis'' - Joaquim Castellà Veterinary Parasitology Universitat Autònoma de Barcelona]]
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| − | *2 common and 2 less common ''Isospora'' species
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| − | *Occasionally can cause disease
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| − | *Little pathogenicity
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| − | | |
| − | *Even if faecal oocyst count is high, other causes of [[Intestine Diarrhoea - Pathology|diarrhoea]] should be looked for
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| − | | |
| − | *''Hepatozoon americanum'' and subclinical ''H. canis'' in [[Bones Hyperplastic and Neoplastic - Pathology#Hepatozoon|periosteal bone formation]]
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| − | **Both are Tick borne diseases
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| − | ***''H. canis'' – ''Rhipicephalus sanguineus''
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| − | ***Ticks become infected by ingesting a blood meal containing macrophages and neutrophils infected with the parasite gamonts -> sexual replication in the gut of the tick -> oocysts containing infective sporozoites -> dogs ingest the tick schizogony occurs in numerous tissues
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| − | ==Coccidia of Cats==
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| − | [[Image:Coccidia.jpg|thumb|right|150px|Coccidia in Cat Faeces - Joel Mills]]
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| − | [[Image:Isospora felis.jpg|thumb|right|150px|''Isospora felis'' - Joaquim Castellà Veterinary Parasitology Universitat Autònoma de Barcelona]]
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| − | *2 common ''Isospora'' species with little clinical significance
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| − | | |
| − | *Oocysts in faeces have to be distinguised from those of ''Toxoplasma'' (smaller) and ''Sarcocytis'' (sporulated or naked sporocyts in faeces)
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| − | | |
| − | ==Coccidia of Rabbits==
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| − | *3 pathogenic ''Eimeria'' species
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| − | **2 in the [[Caecum - Anatomy & Physiology|caecum]]
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| − | **1 in the bile duct
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| − | | |
| − | *''Eimeria steidae''
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| − | **Parasitises the bile duct epithelium
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| − | **Travels via the bile duct to the [[Liver - Anatomy & Physiology|liver]] where it forms large white nodules
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| − | **Oocysts travel in the bile and are passed out in the faeces
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| − | **Causes ascites, [[Intestine Diarrhoea - Pathology|diarrhoea]], weight loss and polyuria
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| − | | |
| − | *Serious disease of both pet and farmed rabbits
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| − | | |
| − | *Treatment is by administration of drugs in drinking water
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| − | **E.g. Toltrazuril
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| − | | |
| − | *Hygiene is the best method of prevention to prevent sporocysts from sporulating
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| − | | |
| − | *Medicated feed can be used in commercial units
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| − | **E.g. Rabenidine
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