Difference between revisions of "Shigella"
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*Not significant cause of infection in domestic animals | *Not significant cause of infection in domestic animals | ||
| − | *Causes | + | *Causes dysentery in humans and primates |
*Enteroinvasive, invading the intestinal mucosa and causing necrosis | *Enteroinvasive, invading the intestinal mucosa and causing necrosis | ||
*Do not cause systemic disease - they do not invade beyond the lamina propria to the bloodstream | *Do not cause systemic disease - they do not invade beyond the lamina propria to the bloodstream | ||
Revision as of 11:26, 6 June 2010
- Not significant cause of infection in domestic animals
- Causes dysentery in humans and primates
- Enteroinvasive, invading the intestinal mucosa and causing necrosis
- Do not cause systemic disease - they do not invade beyond the lamina propria to the bloodstream
- A large plasmid permits survival in cells and is responsible for invasivenss
- Closely related to E. coli - some strains produce Shiga toxin which is related to vero cytotoxin of E. coli
- Cause of dysentery in humans and primates.
Dysentery in Humans and Primates
- Shigella is are enteroinvasive,
- Penetrate the intestinal mucosa.
- Cause necrosis in patches of mucosa.
- Shigella do not invade beyond the lamina propria to the bloodstream.
- Invasive potential is carried by a large plasmid.
- Relates to the ability to survive inside the host cells.
- Some strains produce Shiga toxin.
- Related to vero cytotoxin of some pathogenic strains of E.coli.