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Text replace - 'Neutrophils - WikiBlood' to 'Neutrophils'
***Can have toxic effects in high amounts
***Can have toxic effects in high amounts
**When activated by cytokines, killing mechanisms using free radicals and O2-independent toxins (e.g. nitric oxide) are enhanced
**When activated by cytokines, killing mechanisms using free radicals and O2-independent toxins (e.g. nitric oxide) are enhanced
*'''[[Neutrophils - WikiBlood|Neutrophils]]'''- similar properties to macrophages
*'''[[Neutrophils|Neutrophils]]'''- similar properties to macrophages
**Activated by cytokines such as TNF-alpha, IFN-γ and GM-CSF, [[[[Neutrophils - WikiBlood|Neutrophils]] - WikiBlood|neutrophils]] produce a more intense respiratory burst and extracellular killing is mediated by H2O2
**Activated by cytokines such as TNF-alpha, IFN-γ and GM-CSF, [[[[Neutrophils|Neutrophils]] - WikiBlood|neutrophils]] produce a more intense respiratory burst and extracellular killing is mediated by H2O2
**Present in parasite-infected inflammatory lesions
**Present in parasite-infected inflammatory lesions
**Express Fc and complement receptors- can participate in antibody-dependent cell-mediated cytotoxicity
**Express Fc and complement receptors- can participate in antibody-dependent cell-mediated cytotoxicity
*'''Eosinophils'''- less phagocytic than [[[[Neutrophils - WikiBlood|Neutrophils]] - WikiBlood|neutrophils]], but important in the destruction of larger parasites
*'''Eosinophils'''- less phagocytic than [[[[Neutrophils|Neutrophils]] - WikiBlood|neutrophils]], but important in the destruction of larger parasites
**Most activity is controlled by antigen-specific mechanisms, e.g. binding to worms coated with IgG/IgE increases degranulation
**Most activity is controlled by antigen-specific mechanisms, e.g. binding to worms coated with IgG/IgE increases degranulation
**The killing of some larvae is enhanced by the activity of mast cells, e.g. antigens released by S. mansoni cause IgE-dependent degranulation of mast cells, the products of which selectively attract eosinophils
**The killing of some larvae is enhanced by the activity of mast cells, e.g. antigens released by S. mansoni cause IgE-dependent degranulation of mast cells, the products of which selectively attract eosinophils