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| *Micro pathology: | | *Micro pathology: |
| **Early cases centred upon the bronchiolar alveolar junction with exudation, which extends into neighbouring alveoli | | **Early cases centred upon the bronchiolar alveolar junction with exudation, which extends into neighbouring alveoli |
− | **Exudate contains many [[Neutrophils - WikiBlood|neutrophils]], macrophages and oedema | + | **Exudate contains many [[Neutrophils|neutrophils]], macrophages and oedema |
| **Alveolar capillaries are hyperaemic | | **Alveolar capillaries are hyperaemic |
| **Some haemorrhages in severe cases - later stages contain more cells than fluid | | **Some haemorrhages in severe cases - later stages contain more cells than fluid |
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| ***Type I alveolar epithelial cells are highly sensitive to injury and cannot proliferate in response to injury | | ***Type I alveolar epithelial cells are highly sensitive to injury and cannot proliferate in response to injury |
| ***Necrosis and sloughing of injured type I cells, denuding alveolar spaces of lining epithelium | | ***Necrosis and sloughing of injured type I cells, denuding alveolar spaces of lining epithelium |
− | ***[[Neutrophils - WikiBlood|Neutrophils]] begin to enter alveolar spaces distended with inflammatory oedema | + | ***[[Neutrophils|Neutrophils]] begin to enter alveolar spaces distended with inflammatory oedema |
| **'''Proliferative phase''' | | **'''Proliferative phase''' |
| ***Type II alveolar cells (less sensitive to and can proliferate in response to injury) begin to proliferate within 24 hours and eventually line the alveolar walls denuded of type I cells ***By 6 days cuboidal type II cells can completely line the alveoli | | ***Type II alveolar cells (less sensitive to and can proliferate in response to injury) begin to proliferate within 24 hours and eventually line the alveolar walls denuded of type I cells ***By 6 days cuboidal type II cells can completely line the alveoli |