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====Thrombopoietin ====

====Thrombopoietin ====

Similarly to [[Erythropoiesis - WikiBlood#Regulation|erythropoietin]], thrombopoietin (TPO) regulates the production of thrombocytes by stimulating [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-Meg]] to mature into megakaryocytes. TPO is mainly produced in the liver and acts via a negative feedback system. It binds to TPO receptors on both the megakaryocytes and platelets. Thus if these are in high concentrations in the blood plasma then the level of TPO is kept low, reducing the maturation of [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-Meg]] and production of thrombocytes is reduced.

Similarly to [[Erythropoiesis#Regulation|erythropoietin]], thrombopoietin (TPO) regulates the production of thrombocytes by stimulating [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-Meg]] to mature into megakaryocytes. TPO is mainly produced in the liver and acts via a negative feedback system. It binds to TPO receptors on both the megakaryocytes and platelets. Thus if these are in high concentrations in the blood plasma then the level of TPO is kept low, reducing the maturation of [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-Meg]] and production of thrombocytes is reduced.

==Thrombocyte formation==

==Thrombocyte formation==