Changes

<p>Monocytes are the largest [[Leukocytes|leukocytes]]. They have a large indented nucleus, few granules and constitute about 5% of circulating [[Leukocytes|leukocytes]]. Monocytes are precursors to a number of cells that make up the [[Lymphoreticular System - Anatomy & Physiology|mononuclear phagocytic system]]. Developing in the [[Bone Marrow - Anatomy & Physiology|bone marrow]], monocytes migrate into the circulation where, after approximately three days, they migrate into tissues and differentiate.</p>

<p>Monocytes are the largest [[Leukocytes|leukocytes]]. They have a large indented nucleus, few granules and constitute about 5% of circulating [[Leukocytes|leukocytes]]. Monocytes are precursors to a number of cells that make up the [[Lymphoreticular System - Anatomy & Physiology|mononuclear phagocytic system]]. Developing in the [[Bone Marrow - Anatomy & Physiology|bone marrow]], monocytes migrate into the circulation where, after approximately three days, they migrate into tissues and differentiate.</p>

==Development==

==Development==

<p>Monocytes develop from the bi-potential [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-GM]] stem cell. Further details of this process ([[Leukopoiesis|leukopoiesis]]) can be found [[Leukopoiesis#Monocyte development|here]].</p>

<p>Monocytes develop from the bi-potential [[Haematopoiesis#Colony Forming Units|CFU-GM]] stem cell. Further details of this process ([[Leukopoiesis|leukopoiesis]]) can be found [[Leukopoiesis#Monocyte development|here]].</p>

<p>When monocytes leave the blood stream they then differentiate into a number of cells (all are [[Macrophages|macrophages]]):

<p>When monocytes leave the blood stream they then differentiate into a number of cells (all are [[Macrophages|macrophages]]):

* Connective tissue histiocyte

* Connective tissue histiocyte