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4 bytes added ,  16:32, 12 June 2010
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Text replace - 'IgG' to 'IgG'
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[[Image:LH IgM.png|thumb|150px|right|'''IgM'''<p>1 = IgM monomer</p><p>2 = Heavy chains</p><p>3 = Light chains</p><p>4 =J chain</p><p>5 = Disulfide bonds</p>]]
 
[[Image:LH IgM.png|thumb|150px|right|'''IgM'''<p>1 = IgM monomer</p><p>2 = Heavy chains</p><p>3 = Light chains</p><p>4 =J chain</p><p>5 = Disulfide bonds</p>]]
 
[[Image:IgM.jpg|thumb|right|150px|IgM - B. Catchpole, RVC 2008]]
 
[[Image:IgM.jpg|thumb|right|150px|IgM - B. Catchpole, RVC 2008]]
<p>Is found in high concentrations in blood plasma (below IgG conc.) and is the major Ig produced during primary immune response</p>
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<p>Is found in high concentrations in blood plasma (below [[IgG]] conc.) and is the major Ig produced during primary immune response</p>
 
==Structure==
 
==Structure==
 
<p>IgM is the primordial antibody and, although a monomer, is secreted as a pentamer (five monomers joined by disulphide bonds with two monomers joined by a J chain). This gives it ten identical antigen binding sites although IgM usually has relatively low affinity for its antigen. It heavy chain is type mu (µ ).</p>
 
<p>IgM is the primordial antibody and, although a monomer, is secreted as a pentamer (five monomers joined by disulphide bonds with two monomers joined by a J chain). This gives it ten identical antigen binding sites although IgM usually has relatively low affinity for its antigen. It heavy chain is type mu (µ ).</p>

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