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, 14:00, 23 June 2010
Hyalisation of muscle fibrils of skeletal, intercostal, diaphragmatic and cardiac muscles. Histologically there is '''[[Zenker Degeneration - Pathology|Zenker degeneration]]''' and occasionally also '''[[Myocardial - Pathology#Mineralisation|dystrophic calcification]]'''.
Grossly the condition is seen as grey/yellow streaks on the innermost part of the myocardium.
The condition is associated with '''Vitamin/Selenium deficiency'''. Also known as [[Muscles Degenerative - Pathology#Nutritional myopathy|'''nutritional myopathy''']] or '''[[White Muscle Disease - Pathology|White muscle disease]]'''.
The myocardium of the left ventricle is most affected as it has the largest metabolic demand and so the largest production of anti-oxidants and the greatest need for Vitamin E/Selenium. This manifests clinically as left sided heart failure with clinical signs:
*Pulmonary oedema.
Also:
*Acute ataxia and collapse with the skeletal muscles affected.
Also associated with a diet over-rich in unsaturated fatty acids seen in pigs (Vitamin E/Selenium unavailable as used up by the unsaturated fats).[[Category:Cardiovascular_System_-_Metabolic_Pathology]][[Category:Myocardial_Pathology]]