Difference between revisions of "Tuberculosis - Cattle"
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(Redirected page to Mycobacterium bovis) |
(Created page with '[[Image:Tuberculosis M bovis.jpg|right|thumb|100px|<small><center>Tuberculosis caused by ''M. bovis'' (Image sourced from Bristol Biomed Image Archive with permission)</center></…') |
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− | + | [[Image:Tuberculosis M bovis.jpg|right|thumb|100px|<small><center>Tuberculosis caused by ''M. bovis'' (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]] | |
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+ | *Caused by ''[[Mycobacterium bovis]]'' and ''M. tuberculosis'' | ||
+ | *Reside primarily within macrophages where they multiply and result in characteristic [[Lungs Inflammatory - Pathology#Granulomatous pneumonia|granulomatous inflammation]] (macrophages and giant cells, epithelioid cells) | ||
+ | *Cattle can be infected by inhalation of the organism or through milk | ||
+ | *'''The primary complex''' | ||
+ | **Describes the initial focus of infection at the portal of entry (lungs) plus involvement of regional lymph nodes | ||
+ | **90% of cases exhibit the pulmonary form | ||
+ | **Grossly: | ||
+ | ***Small tubercles in dorsocaudal subpleural areas which progress to larger confluent areas of caseous necrosis | ||
+ | ***Usually start at bronchio-alveolar junction an progress to the alveoli | ||
+ | ***Caseous lesions, may calcify or be encapsulated | ||
+ | ***Multiple foci may coalesce | ||
+ | ***Ulcers in [[Trachea Inflammatory - Pathology|trachea]] and [[Bronchi and Bronchioles Inflammatory - Pathology#Infectious causes of bronchitis or bronchiolitis|bronchi]] due to coughed up bacteria | ||
+ | ***Spreads into [[Pleural Cavity & Membranes Inflammatory - Pathology|pleura]] | ||
+ | **Microscopically: | ||
+ | ***Typical granulomatous inflammation | ||
+ | ***Epitheliod and giant cells at centre of tubercles | ||
+ | ****Macrophages with ingested bacteria, forming epithelioid cells - large vesicular nuclei, abundant pale cytoplasm | ||
+ | ****Giant cells, formed by fusion of macrophages, with multiple nuclei | ||
+ | ***Narrow layer of lymphocytes, mononuclear cells and plasma cells at the periphery of the tubercle | ||
+ | ***With time, peripheral fibroplasia and central necrosis develop | ||
+ | *If the infection is not contained in the primary complex described above, the mycobacteria can disseminate via lymphatics to other organs and lymph nodes | ||
+ | *This can allow the development of '''miliary tuberculosis''', i.e. numerous small foci of infection in many organs/ tissues |
Revision as of 14:04, 30 June 2010
- Caused by Mycobacterium bovis and M. tuberculosis
- Reside primarily within macrophages where they multiply and result in characteristic granulomatous inflammation (macrophages and giant cells, epithelioid cells)
- Cattle can be infected by inhalation of the organism or through milk
- The primary complex
- Describes the initial focus of infection at the portal of entry (lungs) plus involvement of regional lymph nodes
- 90% of cases exhibit the pulmonary form
- Grossly:
- Small tubercles in dorsocaudal subpleural areas which progress to larger confluent areas of caseous necrosis
- Usually start at bronchio-alveolar junction an progress to the alveoli
- Caseous lesions, may calcify or be encapsulated
- Multiple foci may coalesce
- Ulcers in trachea and bronchi due to coughed up bacteria
- Spreads into pleura
- Microscopically:
- Typical granulomatous inflammation
- Epitheliod and giant cells at centre of tubercles
- Macrophages with ingested bacteria, forming epithelioid cells - large vesicular nuclei, abundant pale cytoplasm
- Giant cells, formed by fusion of macrophages, with multiple nuclei
- Narrow layer of lymphocytes, mononuclear cells and plasma cells at the periphery of the tubercle
- With time, peripheral fibroplasia and central necrosis develop
- If the infection is not contained in the primary complex described above, the mycobacteria can disseminate via lymphatics to other organs and lymph nodes
- This can allow the development of miliary tuberculosis, i.e. numerous small foci of infection in many organs/ tissues