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Tetanus - Horse (view source)

Revision as of 16:05, 5 July 2010

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==Signalment==
 
==Signalment==
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''Clostridium tetani'' generally cause infection via wound contamination. Cuts or deep puncture wounds are most commonly infected. ''C. tetani''produces tetanospasmin, a neurotoxin that inhibits the release of the neurotransmitters GABA and glycine from interneurons in the spinal cord and brain. Thi causes increased excitation of the brainstem and motor neurons, leading to unopposed muscle contraction.
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* [[Clostridium tetani|''Clostridium tetani'']] generally cause infection via wound contamination.
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** Cuts or deep puncture wounds are most commonly infected.
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* [[Clostridium tetani|''Clostridium tetani'']] produces tetanospasmin, a neurotoxin.
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** Tetanospasmin inhibits the release of the neurotransmitters GABA and glycine from interneurons in the spinal cord and brain.
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* Without the usual inhibitory influence of glycine and GABA, there is increased excitation of the brainstem and motor neurons.
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** This leads to unopposed muscle contraction.
   
*** The frequency of action potentials at the neuromuscular junctions increases above a threshold.
 
*** The frequency of action potentials at the neuromuscular junctions increases above a threshold.
 
*** Above this threshold, muscle fibres enter a state of tetanus.
 
*** Above this threshold, muscle fibres enter a state of tetanus.
Signarski
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