− | Hypercalcaemia is present in 50%-90% of dogs with anal sac adenocarcinoma. This is thought to occur due to the expression of a gene for parathyroid hormone-related peptide (PTH-rP)by the tumour which has actions similar to parathyroid hormone. | + | Hypercalcaemia is present in 50%-90% of dogs with anal sac adenocarcinoma. This is thought to occur due to the expression of a gene for parathyroid hormone-related peptide(PTH-rP)by the tumour. Parathyroid hormone-related peptide(PTH-rP)has actions similar to parathyroid hormone where it acts to increase calcium levels in the blood. . In severe cases of hypercalcaemia organ function can become impaired |