Changes

==History and Clinical signs==

==History and Clinical signs==

FECoV may cause mild respiratory symptoms and diarrhoea but is often asymptomatic.

FECoV may cause mild respiratory symptoms and diarrhoea but is often asymptomatic.

==Diagnosis==

==Diagnosis==

FIP should be suspected in all cases of chronic weight loss or recurrent fever unresponsive to antibiotics, particularly in multiple cat situations.

FIP should be suspected in all cases of chronic weight loss or recurrent fever unresponsive to antibiotics, particularly in multiple cat situations.

Simple serology is impossible as most cats will have antibody to FECoV.

Simple serology is impossible as most cats will have antibody to FECoV.

===Laboratory Tests===

===Laboratory Tests===

Four indicators can be used for diagnosis:

Four indicators can be used for diagnosis:

*High FECoV Antibody titres

*High FECoV Antibody titres

==Pathogenesis==

==Pathogenesis==

Weeks, months or years may intervene between localized primary FECoV infection and FIP development. FECoV replicates in the gut, but FIP spreads systemically in the circulation. FIP then gains the ability to replicate in [[Monocytes|monocytes]] and macrophages.

Weeks, months or years may intervene between localized primary FECoV infection and FIP development. FECoV replicates in the gut, but FIP spreads systemically in the circulation. FIP then gains the ability to replicate in [[Monocytes|monocytes]] and macrophages.

====Gross====

====Gross====

'''Wet form'''

'''Wet form'''

====Histological====

====Histological====

Multifocal pyogranulomas on serosa and throughout gut wall. Infiltration by mononuclear cells, [[Lymphocytes|lymphocytes]], plasma cells, [[Macrophages|  macrophages]] and a few[[Neutrophils|neutrophils]]. [[Necrosis - Pathology|Necrosis]] and vasculitis will also be seen.

Multifocal pyogranulomas on serosa and throughout gut wall. Infiltration by mononuclear cells, [[Lymphocytes|lymphocytes]], plasma cells, [[Macrophages|  macrophages]] and a few[[Neutrophils|neutrophils]]. [[Necrosis - Pathology|Necrosis]] and vasculitis will also be seen.

==Treatment==

==Treatment==

Immunomodulators including interferon have been used to control the virus and Dr. Diane Addie at Glasgow vet school has found that cats do respond to this form of treatment.   

Immunomodulators including interferon have been used to control the virus and Dr. Diane Addie at Glasgow vet school has found that cats do respond to this form of treatment.   

Antibody tests are available to certify FECoV-free cat houses.

Antibody tests are available to certify FECoV-free cat houses.

==Prognosis==

==Prognosis==