| Improvement in most clinical signs should be noted within 1-3 weeks of commencing treatment. Colic or diarrhoea should resolve within 48 hours.<ref name="Sanchez">Sanchez, L.C (2010) 'Diseases Of The Stomach' in Reed, S.M, Bayly, W.M. and Sellon, D.C (2010) '''Equine Internal Medicine''' (Third Edition), Saunders, Chapter 15.</ref> Complications related to gastric ulcers are most frequent and severe in foals and include perforation, delayed gastric emptying, gastroesophageal reflux and oesophagitis, and megaoesophagus secondary to chronic gastroesophageal reflux. Sudden gastric perforation without prior signs occurs sporadically in foals.<ref name="Merck">Merck & Co (2008) The Merck Veterinary Manual (Eighth Edition), Merial</ref>Ulcers in the proximal duodenum or at the pylorus can cause fibrosis and stricture. The latter complication is seen in both foals and adult horses.<ref name="Merck">Merck & Co (2008) The Merck Veterinary Manual (Eighth Edition), Merial</ref> In mature animals, the most common complication is the recurrence of EGUS after treatment has ceased. This is typically because the inciting managemental causes have not been altered. | | Improvement in most clinical signs should be noted within 1-3 weeks of commencing treatment. Colic or diarrhoea should resolve within 48 hours.<ref name="Sanchez">Sanchez, L.C (2010) 'Diseases Of The Stomach' in Reed, S.M, Bayly, W.M. and Sellon, D.C (2010) '''Equine Internal Medicine''' (Third Edition), Saunders, Chapter 15.</ref> Complications related to gastric ulcers are most frequent and severe in foals and include perforation, delayed gastric emptying, gastroesophageal reflux and oesophagitis, and megaoesophagus secondary to chronic gastroesophageal reflux. Sudden gastric perforation without prior signs occurs sporadically in foals.<ref name="Merck">Merck & Co (2008) The Merck Veterinary Manual (Eighth Edition), Merial</ref>Ulcers in the proximal duodenum or at the pylorus can cause fibrosis and stricture. The latter complication is seen in both foals and adult horses.<ref name="Merck">Merck & Co (2008) The Merck Veterinary Manual (Eighth Edition), Merial</ref> In mature animals, the most common complication is the recurrence of EGUS after treatment has ceased. This is typically because the inciting managemental causes have not been altered. |
| + | Potential complications of GDUD: delayed gastric emptying, gastrooesphageal reflux, gastric or duodenal rupture, pyloric or duodenal stricture, ascending cholangitis. Severe squamous and oesophageal ulceration and aspiration pnemonia can occur secondary to gastroesophageal reflux (24, 84-87 in Sanchez) |