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Chronic Inflammation - Introduction (view source)
Revision as of 11:27, 4 August 2010
, 11:27, 4 August 2010Created page with "==Introduction== * Chronic inflammation may: ** Follow on from an unresolved acute inflammation. ** Be chronic from the beginning. *** Is usually of slow onset and long duration..."
==Introduction==
* Chronic inflammation may:
** Follow on from an unresolved acute inflammation.
** Be chronic from the beginning.
*** Is usually of slow onset and long duration, and very insidious in nature.
*** There is a slow progressive destruction of the original tissue.
* Chronic inflammation is characterised by cellular infiltration and proliferation of local connective tissue.
** Often found around focal areas of necrosis.
==Cells==
* The principal inflammatory cells involved are [[Lymphocytes|lymphocytes]] and [[Macrophages|macrophages]].
** Fibroblasts and vascular endothelium also have important roles.
===Accumulation of Macrophages===
* Under certain circumstances, macrophages accumulate.
*# Impaired digestive ability of the macrophages to cope with foreign material.
*#* E.g. thorns, sutures, grit etc.
*# The irritant being able to coat itself with host antigens.
*#* E.g. [[:Category:Actinobacillus species|''Actinobacillus'']] bacteria form enveloping 'clubs'.
*# The irritant's own coating being impervious to digestion by the macrophage.
*#* E.g. tubercle bacillus and fungi.
===Fibroblasts ===
* Derived from local connective tissue cells.
* Involved in the organisation of damaged tissue.
** Replacement repair.
===Endothelium===
* As well as fibroplasia (organisation) and macrophages mopping up debris, the vascular endothelium proliferates into the organising tissue.
* Endothelium is a prominent component of the 'pyogenic membrane’ in abscess formation.
** The vessels bring [[Neutrophils|neutrophils]] into the centre of the abscess.
[[Category:Chronic Inflammation]][[Category:To Do - Blood]]
* Chronic inflammation may:
** Follow on from an unresolved acute inflammation.
** Be chronic from the beginning.
*** Is usually of slow onset and long duration, and very insidious in nature.
*** There is a slow progressive destruction of the original tissue.
* Chronic inflammation is characterised by cellular infiltration and proliferation of local connective tissue.
** Often found around focal areas of necrosis.
==Cells==
* The principal inflammatory cells involved are [[Lymphocytes|lymphocytes]] and [[Macrophages|macrophages]].
** Fibroblasts and vascular endothelium also have important roles.
===Accumulation of Macrophages===
* Under certain circumstances, macrophages accumulate.
*# Impaired digestive ability of the macrophages to cope with foreign material.
*#* E.g. thorns, sutures, grit etc.
*# The irritant being able to coat itself with host antigens.
*#* E.g. [[:Category:Actinobacillus species|''Actinobacillus'']] bacteria form enveloping 'clubs'.
*# The irritant's own coating being impervious to digestion by the macrophage.
*#* E.g. tubercle bacillus and fungi.
===Fibroblasts ===
* Derived from local connective tissue cells.
* Involved in the organisation of damaged tissue.
** Replacement repair.
===Endothelium===
* As well as fibroplasia (organisation) and macrophages mopping up debris, the vascular endothelium proliferates into the organising tissue.
* Endothelium is a prominent component of the 'pyogenic membrane’ in abscess formation.
** The vessels bring [[Neutrophils|neutrophils]] into the centre of the abscess.
[[Category:Chronic Inflammation]][[Category:To Do - Blood]]