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Although the incubation period for classical swine fever is generally less than ten days, in the field it may take up to four weeks for clinical signs to become apparent in a population. Disease severity varies with virulence, immune status and the age of the animal: this means that although acute, chronic and congenital forms of the disease can be appreciated, there is no "classic" disease presentation.
 
Although the incubation period for classical swine fever is generally less than ten days, in the field it may take up to four weeks for clinical signs to become apparent in a population. Disease severity varies with virulence, immune status and the age of the animal: this means that although acute, chronic and congenital forms of the disease can be appreciated, there is no "classic" disease presentation.
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In the acute form, animals are almost always pyrexic. In piglets under 12 weeks old the fever may exceed 40°, but in adults temperatures may be no higher than 39.5°. Lethargy, conjunctivitis, lymphomegaly may be seen, as well as respiratory signs and diarrhoea. Neurological signs such as gait abnormalities, incoordination and convulsions are also common. The most telling sign of classical swine fever is haemorrhage of the skin. These arise in the second or third week post-infection on the ear, tail, abdomen and medial aspect of the limbs and persist until death.
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In the acute form, animals are almost always pyrexic. In piglets the fever may exceed 40°, but in adults temperatures may be no higher than 39.5°. Lethargy, conjunctivitis, lymphomegaly may be seen, as well as respiratory signs and diarrhoea. Neurological signs such as gait abnormalities, incoordination and convulsions are also common. The most telling sign of classical swine fever is haemorrhage of the skin. These arise in the second or third week post-infection on the ear, tail, abdomen and medial aspect of the limbs and persist until death. CSF virus also causes severe leukopenia and immunosuppression, which can to secondary enteric or respiratory infections which may cause confusion by masking or overlapping the more typical signs of CSF. With increasing age of infected animals, the clinical signs of acute CSF become less specific and diagnosis more difficult. Alao, acute classical swine fever is indistinguishable from African swine fever and so care must be taken when formulating a diagnosis. Other differential diagnoses for acute CSF are erysipelas, PRRS, purpura haemorragica, PWMS, PDNS, Salmonellosis and Pasteurellosis. Classical swine fever should also be considered in any pyrexic enteric or respiratory disease cases that are not responsive to antibiotics.  
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CSF virus causes severe leukopenia and immunosuppression,
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which often leads to secondary
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Fig. 1. Neurological signs of CSF. The back is hunched
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up and the hind legs are pushed under the abdomen.
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Wasting and haemorrhages on ears and hind legs are
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visible.
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Fig. 2. Swollen lymph nodes of the small intestine and
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necrosis of the ileocaecal valve (centre).
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12 THE VETERINARY JOURNAL, 165, 1
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enteric or respiratory infections. The signs of these
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secondary infections can mask or overlap the most
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typical signs of CSF and may mislead the veterinarian
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(Depner et al., 1999).
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In general, the acute form of African swine fever
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leads to a very similar clinical and pathological picture.
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CSF must also be considered in the differential
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diagnosis of erysipelas, porcine reproductive and
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respiratory syndrome (PRRS), cumarin poisoning,
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purpura haemorragica, post-weaning multisystemic
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wasting syndrome (PWMS), porcine dermatitis and
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nephropathy syndrome (PDNS), Salmonella or
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Pasteurella infections or any enteric or respiratory
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syndrome with fever not responding to antibiotic
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treatment.
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With increasing age of the infected pigs (fattening
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and breeding animals) the clinical signs are less
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specific and recovery with production of antibodies
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can occur. Antibodies against CSF virus become
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detectable 2–3 weeks postexposure to CSF virus
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(Laevens et al., 1998).
   
CHRONIC COURSE OF CLASSICAL SWINE
 
CHRONIC COURSE OF CLASSICAL SWINE
 
FEVER VIRUS INFECTION
 
FEVER VIRUS INFECTION
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