Difference between revisions of "Case 1"

Revision as of 11:58, 31 August 2007

Signalment

7 year old
Male neutered
Domestic short haired cat

History

Fully vaccinated
Sudden death at home
No other clinical abnormalities

Imaging

Haematology/Biochemistry

Gross Pathology

Hypertrophic cardiomyopathy (cat). Courtesy of T. Scase

The following data and pictures were taken at post-mortem examination:

Cardiovascular system:

Heart has a globoid shape
Ventricular wall measurements:
- Interventricular septum; 12mm
- Right ventricular wall; 3mm
- Left ventricular wall; 10mm
Pericardium is fatty, shiny and intact

Hypertrophic cardiomyopathy (cat). Courtesy of T. Scase

No embolic thrombi were found in the abdominal aorta.

No further abnormalities were found.

Histopathology

Histology; hypertrophic cardiomyopathy. Courtesy of K. Hughes

The cardiac myocytes are multifocally widely spaced and infiltrated by streams of spindle shaped cells (fibroblasts). Staining with Massons Trichrome confirms the presence of large, multifocal areas of fibrosis within the inner third of the myocardium and extending to the endocardial surface. Multifocally the fibrosis surrounds individual atrophied myocytes. There is mural thickening (smooth muscle hypertrophy) of the intramyocardial arteries.

@@ Line 19: / Line 19: @@
 The following data and pictures were taken at post-mortem examination:
 '''Cardiovascular system''':
 *Heart has a ''globoid'' shape
 *Ventricular wall measurements:
-**Interventricular septum; 12mm[[Image:hypertrophic cardiomyopathy 2.jpg|right|thumb|125px|<small><center>'''Hypertrophic cardiomyopathy (cat)'''. Courtesy of T. Scase</center></small>]]
+**Interventricular septum; 12mm
 **Right ventricular wall; 3mm
 **Left ventricular wall; 10mm
 *Pericardium is fatty, shiny and intact
+[[Image:hypertrophic cardiomyopathy 2.jpg|right|thumb|125px|<small><center>'''Hypertrophic cardiomyopathy (cat)'''. Courtesy of T. Scase</center></small>]]
 No embolic thrombi were found in the abdominal aorta.
-The other body systems were examined.<br>
 No further abnormalities were found.
-<br><br><br>
 ==Histopathology==
-[[Image:Case pic 3.jpg|right|thumb|125px|<small><center>'''Histology'''. Courtesy of K. Hughes</center></small>]]
+[[Image:Case pic 3.jpg|left|thumb|125px|<small><center>'''Histology; hypertrophic cardiomyopathy'''. Courtesy of K. Hughes</center></small>]]
-Samples were taken for histological examination (Stained with H and E):
-*The cardiac myocytes are multifocally widely spaced and infiltrated by streams of spindle shaped cells (fibroblasts).
-[[Image:Case pic 4.jpg|right|thumb|125px|<small><center>'''Massons Trichrome'''. Courtesy of K. Hughes</center></small>]]
-Some sections were stained with Massons Trichrome:
-* This confirmed the presence of large, multifocal areas of fibrosis within the inner third of the myocardium and extending to the endocardial surface.
-* Multifocally the fibrosis surrounds individual atrophied myocytes.
-* There is mural thickening (smooth muscle hypertrophy) of the intramyocardial arteries.
-<br><br>
-==Diagnosis==
-The gross post mortem findings indicated a '''severe hypertrophic cardiomyopathy''' which was confirmed on histology.
-The fibrosis seen is a common sequale to this type of disease.  The hypertrophy in the ventricular wall limits blood supply to the inner third of myocardium.  Reduced perfusion stimulates replacement of degenerate myocytes with fibrous tissue, extending into the endocardium.
-[[Category:Lost]]
+The cardiac myocytes are multifocally widely spaced and infiltrated by streams of spindle shaped cells (fibroblasts). Staining with Massons Trichrome confirms the presence of large, multifocal areas of fibrosis within the inner third of the myocardium and extending to the endocardial surface. Multifocally the fibrosis surrounds individual atrophied myocytes. There is mural thickening (smooth muscle hypertrophy) of the intramyocardial arteries.