Changes

Animals suffering from extra-hepatic biliary obstruction (EHBO) are often profoundly unwell.  The reduced flow of bile salts into the gastro-intestinal (GI) tract allows GI bacteria to proliferate and eventually translocate across the intestinal wall.  In addition, biliary stasis reduces the function of Kupffer cells within the liver, reducing their ability to remove and neutralise translocated bacteria from the portal blood.  These animals should be stabilised adequately before any surgical repair is attempted.

Animals suffering from extra-hepatic biliary obstruction (EHBO) are often profoundly unwell.  The reduced flow of bile salts into the gastro-intestinal (GI) tract allows GI bacteria to proliferate and eventually translocate across the intestinal wall.  In addition, biliary stasis reduces the function of Kupffer cells within the liver, reducing their ability to remove and neutralise translocated bacteria from the portal blood.  These animals should be stabilised adequately before any surgical repair is attempted.

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==References==