Changes

{{unfinished}}

{{review}}

{{toplink

{{toplink

|linkpage =WikiDrugs

|linkpage =WikiDrugs

}}

}}

Fungal Infections are a common cause of disease in both animals and man. Many of the [[fungi|fungi and yeasts]] that cause disease in the animal population are zoonotic and so owners and vets a like are also at risk of infection. As this group of organisms are eukaryotic cells, trying to combat them becomes are more complex and challenging prospect as they have the ability to be toxic to the animal's own cells. Therfore it is important to understand how this drugs work, their potential side effects and which species they are active against.

Fungal infections are a common cause of disease in both animals and man. Many of the [[fungi|fungi and yeasts]] that cause disease in the animal population are zoonotic and so owners and vets alike are also at risk of infection. As this group of organisms are eukaryotic cells, trying to combat them becomes a more complex and challenging prospect as they have the ability to be toxic to the animal's own cells. Therefore it is important to understand how these drugs work, their potential side effects and which species they are active against.

'''Enilconazole'''

'''Enilconazole'''

* It is not absorbed after oral dosing and so has a wide safety margin.

* It is not absorbed after oral dosing and so has a wide safety margin.

* It is only liscensed for topical ringworm treatment, but has been used off-liscense (following the cascade) for ''Malassezia pachydermatitis'' infections and nasal aspegillosis.

* It is only licensed for topical ringworm treatment, but has been used off-license (following the cascade) for ''Malassezia pachydermatitis'' infections and nasal aspergillosis.

* It is metabolised by the liver into inactive compounds that are then excreted in bile.

* It is metabolised by the liver into inactive compounds that are then excreted in bile.

* It has been used for deep mycoses therapy, treatment of ringworm and nasal aspergillosis.

* It has been used for deep mycoses therapy, treatment of ringworm and nasal aspergillosis.

* Toxicity is low but can result in inappetance, pruritis, alopecia and lightening of hair.

* Toxicity is low but can result in inappetance, pruritus, alopecia and lightening of hair.

* It has been known to be tetragenic and embryotoxic and so shouldn't be used with pregnant animals.

* It has been known to be tetragenic and embryotoxic and so shouldn't be used with pregnant animals.

===Triazoles===

===Triazoles===

==Griseofluvin==

==Griseofulvin==

* This drug is a natural antifungal produced by ''Penicillium griseofulvum'', it works by interacting with fungal microtubules and halts mitosis and so is '''fungistatic'''.

* This drug is a natural antifungal produced by ''Penicillium griseofulvum'', it works by interacting with fungal microtubules and halts mitosis and so is '''fungistatic'''.

* It has a narrow spectrum of activity only really inhibiting the growth of dermatophytes.

* It has a narrow spectrum of activity only really inhibiting the growth of dermatophytes.

* It is eliminated by hepatic metabolism.

* It is eliminated by hepatic metabolism.

* It is '''teratogenic''', so should never be given to pregnant animals. It can exacerbate liver damage and so function should be monitored. There have been reports in cats of bone marrow toxicity.

* It is '''teratogenic''', so should never be given to pregnant animals. It can exacerbate liver damage and so function should be monitored. There have been reports in cats of bone marrow toxicity.

==Flucytosine==

==Flucytosine==

* It is very narrow spectrum and only works against ''Candida'' species and ''Cryptococcus neoformans'' infections.

* It is very narrow spectrum and only works against ''Candida'' species and ''Cryptococcus neoformans'' infections.

* It has very good oral bioavailability and distrubutes widely throughout all tissue including the CSF.

* It has very good oral bioavailability and distrubutes widely throughout all tissue including the CSF.