Changes

'''Enilconazole'''

'''Enilconazole'''

* It is not absorbed after oral dosing and so has a wide safety margin.

* It is not absorbed after oral dosing and so has a wide safety margin.

* It is only liscensed for topical ringworm treatment, but has been used off-liscense (following the cascade) for ''Malassezia pachydermatitis'' infections and nasal aspegillosis.

* It is only licensed for topical ringworm treatment, but has been used off-license (following the cascade) for ''Malassezia pachydermatitis'' infections and nasal aspergillosis.

* It is metabolised by the liver into inactive compounds that are then excreted in bile.

* It is metabolised by the liver into inactive compounds that are then excreted in bile.

* It has been used for deep mycoses therapy, treatment of ringworm and nasal aspergillosis.

* It has been used for deep mycoses therapy, treatment of ringworm and nasal aspergillosis.

* Toxicity is low but can result in inappetance, pruritis, alopecia and lightening of hair.

* Toxicity is low but can result in inappetance, pruritus, alopecia and lightening of hair.

* It has been known to be tetragenic and embryotoxic and so shouldn't be used with pregnant animals.

* It has been known to be tetragenic and embryotoxic and so shouldn't be used with pregnant animals.

===Triazoles===

===Triazoles===

==Griseofluvin==

==Griseofulvin==

* This drug is a natural antifungal produced by ''Penicillium griseofulvum'', it works by interacting with fungal microtubules and halts mitosis and so is '''fungistatic'''.

* This drug is a natural antifungal produced by ''Penicillium griseofulvum'', it works by interacting with fungal microtubules and halts mitosis and so is '''fungistatic'''.

* It has a narrow spectrum of activity only really inhibiting the growth of dermatophytes.

* It has a narrow spectrum of activity only really inhibiting the growth of dermatophytes.

* It is eliminated by hepatic metabolism.

* It is eliminated by hepatic metabolism.

* It is '''teratogenic''', so should never be given to pregnant animals. It can exacerbate liver damage and so function should be monitored. There have been reports in cats of bone marrow toxicity.

* It is '''teratogenic''', so should never be given to pregnant animals. It can exacerbate liver damage and so function should be monitored. There have been reports in cats of bone marrow toxicity.

==Flucytosine==

==Flucytosine==

*[[Fungi|Fungal infections]]

*[[Fungi|Fungal infections]]