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[[Image:ImageNeeded.png|thumb|200px|right|'''''']]
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[[Image:virusimmunity.jpg|thumb|200px|right|'''''']]
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'''Humoral'''
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==Humoral==
*Production of '''neutralising antibody'''
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The humoral response to viruses involves the production of '''neutralising antibody''' and '''Antibody-dependent cell mediated cytotoxicity (ADCC)'''. [[Immunoglobulins|Antibody]]-labelled cells can be targeted by [[Lymphocytes#Natural Killer (NK) cells|NK Cells]] as another defence against viral infection.  The antibody produced against viral protein can attach to infected cells during their budding phase, which effectively labels them for [[Lymphocytes#Natural Killer (NK) cells|NK]] targeting. [[Lymphocytes#Natural Killer (NK) cells|NK]] cells express Fcγ receptors with which to detect such cells.  Once activated, they release a host of enzymes to induce apoptosis of the budding cell.
*'''Antibody-dependent cell mediated cytotoxicity (ADCC)'''  
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[[Immunoglobulins|Antibody]]-labelled cells can be targeted by [[Lymphocytes#Natural Killer (NK) cells|NK Cells]] as another defence against viral infection.  Antibody produced against viral protein can attach to infected cells during their budding phase, which effectively labels them for [[Lymphocytes#Natural Killer (NK) cells|NK]] targeting. [[Lymphocytes#Natural Killer (NK) cells|NK]] cells express Fcγ receptors with which to detect such cells.  Once activated, they release a host of enzymes to induce apoptosis of the budding cell.
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==Cell-Mediated==
'''Cell-Mediated'''
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The cell-mediated response to viruses involves [[Lymphocytes#Cytotoxic CD8+|CD8+ T-cell]] mediated killing of virus infected cells. They are the main cells involved in the immune response to '''intracellular''' virus infection. Viruses are detected by the recognition of [[Major Histocompatability Complexes#MHC I|MHC I]]-peptide complex and infected cells are killed by apoptosis. perforin and granzymes activate the caspase cascade and Fas-ligand triggers the Fas-mediated apoptosis pathway. Cytotoxic [[Cytokines|cytokines]] (especially TNF-α & TNF-β lymphotoxin) act on TNF receptors to induce programmed cell death.
*[[Lymphocytes#Cytotoxic CD8+|CD8+ T-cell]] mediated killing of virus infected cells
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**Main cells involved in the immune response to '''intracellular''' virus infection
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**Recognition of [[Major Histocompatability Complexes#MHC I|MHC I]]-peptide complex  
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**Infected cells are killed by apoptosis
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***Perforin and granzymes activate the caspase cascade
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***Fas-ligand triggers the Fas-mediated apoptosis pathway
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***Cytotoxic [[Cytokines|cytokines]] (especially TNF-α & TNF-β lymphotoxin) act on TNF receptors to induce programmed cell death
      
<big>'''Also see [[Immunity to Viruses]]'''</big>
 
<big>'''Also see [[Immunity to Viruses]]'''</big>
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