Changes

Anaesthetic agents have a number of side effects and it is often necessary to treat these issues using some of the following drugs -  

Anaesthetic agents have a number of side effects and it is often necessary to treat these issues using some of the following drugs -  

==Dobutamine==

==Dobutamine==

'''Dobutamine''' is a synthetic catecholamine which acts as a β1 selective adrenoceptor agonist. Dobutamine is a ''sympathomimetic'' and postive inotrope. It exerts this effect by stimulating β1 adrenergic receptors. This causes a rise in cAMP though the activation of adenylate cyclase. This increase causes an increase in slow inward calcium currents. It also increases calcium storage in the sarcoplasmic reticulum making more calcium available to contractile muscle fibres, thereby increasing myocardial contractility. It also acts at β1 and β2 receptors in the peripheral vasculature.  

'''''Dobutamine is used in patients with heart failure. It can be used as emergency treatment in patients with cardiogenic shock. It can be used in anaesthesia when there is hypotension or bradycardia due to poor myocardial contractility.'''''

 

Dobutamine is a synthetic catecholamine which acts as a β1 selective adrenoceptor agonist. Dobutamine is a ''sympathomimetic'' and postive inotrope. It exerts this effect by stimulating β1 adrenergic receptors. This causes a rise in cAMP though the activation of adenylate cyclase. This increase causes an increase in slow inward calcium currents. It also increases calcium storage in the sarcoplasmic reticulum making more calcium available to contractile muscle fibres, thereby increasing myocardial contractility. It also acts at β1 and β2 receptors in the peripheral vasculature.  

Dobutamine has a low half life and so is given via a continuous rate intravenous infusion. Due to its potential side effects however, it can only be administered for a maximum of 48 hours.  

Dobutamine has a low half life and so is given via a continuous rate intravenous infusion. Due to its potential side effects however, it can only be administered for a maximum of 48 hours.  

*Hypertension

*Hypertension

*Cardiac arrhythmias

*Cardiac arrhythmias

==Dopamine==

==Dopamine==