5,582
edits
Changes
Jump to navigation
Jump to search
→Thrombocytopaenia
==Thrombocytopaenia==
==Thrombocytopaenia==
Thrombocytopaenia is a common haematological abnormality as platelet numbers are subject to fluctuation in a number of diseases. Care should be taken, however to ensure that this finding is not caused by an artefact of sampling where platelet clumps have formed. The normal blood platelet concentration of the dog is 175-500x10^9 but clinical disease is not usually observed until this level falls below 50x10^9 and spontaneous haemorrhage is observed only when the level falls below 20x10^9. Reductions in platelet numbers may be caused by a failure to produce adequate amounts in the bone marrow during megakaryopoiesis, or an increased destruction of existing platelets or sequestration of platelets outside of the circulation.
Thrombocytopaenia is a common haematological abnormality as platelet numbers are subject to fluctuation in a number of diseases. Care should be taken, however to ensure that this finding is not caused by an artefact of sampling where platelet clumps have formed. The normal blood platelet concentration of the dog is 175-500x10^9 but clinical disease is not usually observed until this level falls below 50x10^9 and spontaneous haemorrhage is observed only when the level falls below 20x10^9. Reductions in platelet numbers may be caused by a failure to produce adequate amounts in the bone marrow during [[Thrombopoiesis|megakaryopoiesis]], or an increased destruction of existing platelets or sequestration of platelets outside of the circulation.
*Diseases that cause '''[[Bone Marrow - Anatomy & Physiology|bone marrow]] suppression'''
*Diseases that cause '''[[Bone Marrow - Anatomy & Physiology|bone marrow]] suppression'''
**'''Aplastic anaemia''' caused by ingestion of bracken or administration of oestrogens, [[Chloramphenicol|chloramphenicol]] or [[Sulphonamides|sulphonamide]] antibiotics. Prolonged use of phenylbutazone or salicylate may cause the same disease.
**'''Aplastic anaemia''' caused by ingestion of bracken or administration of oestrogens, [[Chloramphenicol|chloramphenicol]] or [[Sulphonamides|sulphonamide]] antibiotics. Prolonged use of phenylbutazone or salicylate may cause the same disease.