Changes

Diseases that cause '''increased destruction of platelets'''

Diseases that cause '''increased destruction of platelets'''

*'''[[Immune Mediated Thrombocytopaenia|Immune-mediated thrombocytopaenia]]''' is a common autoimmune disease that leads to the production of antibodies against platelets and their subsequent destruction by cells of the [[Monocytes|monocyte]] phagocyte system (MPS).

*'''[[Immune Mediated Thrombocytopaenia|Immune-mediated thrombocytopaenia]]''' is a common autoimmune disease that leads to the production of antibodies against platelets and their subsequent destruction by cells of the [[Monocytes|monocyte]] phagocyte system (MPS).

*'''Infectious diseases''' that cause destruction of platelets include [[Bovine Viral Diarrhoea Virus|bovine viral diarrhoea (BVD)]], [[Classical Swine Fever|classical swine fever]] and [[Infectious Canine Hepatitis|infectious canine hepatitis]].  The parasites ''[[Ehrlichia platys|Anaplasma platys]]'', ''[[Ehrlichia phagocytophila|Anaplasma phagocytophilum]]'' and ''[[Ehrlichia canis]]'' may also cause infectious thrombocytopaenia.  Any severe bacterial infection, including those caused by [[:Category:Staphylococcus species|''Staphylococci'']] and the Gram negative bacteria that produce endotoxins (e.g. [[:Category:Pseudomonas and Burkholderia species|''Pseudomonas spp.'']] or [[Salmonella|''Salmonella spp.'']]) may also result in the destruction of platelets.

*'''Infectious diseases''' that cause destruction of platelets include [[Bovine Viral Diarrhoea Virus|bovine viral diarrhoea (BVD)]], [[Classical Swine Fever|classical swine fever]] and [[Infectious Canine Hepatitis|infectious canine hepatitis]].  The parasites [[Ehrlichia platys|Anaplasma platys]], [[Ehrlichia phagocytophila|Anaplasma phagocytophilum]] and [[Ehrlichia canis]] may also cause infectious thrombocytopaenia.  Any severe bacterial infection, including those caused by [[:Category:Staphylococcus species|Staphylococci]] and the Gram negative bacteria that produce endotoxins (e.g. [[:Category:Pseudomonas and Burkholderia species|Pseudomonas spp.]] or [[Salmonella|Salmonella spp.]]) may also result in the destruction of platelets.

Diseases that cause '''sequestration of platelets''' usually involve some enlargement of the spleen, as this is the major organ where platelets are stored outside of the circulation.  A common example would be [[Haemangiosarcoma|haemangiosarcoma]] of the spleen and liver. Splenic enlargement under general anaesthesia maintained with agents such as [[Barbiturates|barbiturates]] and [[Phenothiazines|phenothiazines]] can also lead to sequestration of platelets.

Diseases that cause '''sequestration of platelets''' usually involve some enlargement of the spleen, as this is the major organ where platelets are stored outside of the circulation.  A common example would be [[Haemangiosarcoma|haemangiosarcoma]] of the spleen and liver. Splenic enlargement under general anaesthesia maintained with agents such as [[Barbiturates|barbiturates]] and [[Phenothiazines|phenothiazines]] can also lead to sequestration of platelets.