Changes

==Thrombocytosis==

==Thrombocytosis==

Increases in platelets above the normal level may occur due to '''physiological''' or '''pathological''' processes.   

Increased platelet number above normal levels may occur due to physiological or pathological processes.   

*Physiological

 

**'''Splenic contraction''' pushes sequestered platelets into the circulation.  This phenomenon is especially marked in horses which have a muscular splenic capsule.   

Physiological causes include:

**'''Splenectomy''' prevents the sequestration of platelets in the spleen, resulting in constantly increased levels of platelets.

*'''Splenic contraction''' which pushes sequestered platelets into the circulation.  This phenomenon is especially marked in '''horses''' which have a muscular splenic capsule.   

**As part of a response to '''[[Anaemia - Introduction|anaemia]]''', a '''reactive thrombocytosis''' is often documented and this may precede signs of regeneration.

*'''Splenectomy''' prevents the sequestration of platelets in the spleen, resulting in consistently increased levels of platelets.

*Pathological

*As part of a response to [[Anaemia - Introduction|anaemia]] a '''reactive thrombocytosis''' is often documented and this may precede signs of regeneration.

**'''Essential thrombocythaemia''' is a rare myeloproliferative disease that results in the excessive production of platelets which function abnormally.  Affected animals suffer from bouts of spontaneous haemorrhage.

 

Pathological

*'''Essential thrombocythaemia''' is a rare myeloproliferative disease that results in the excessive production of platelets which function abnormally.  Affected animals suffer from bouts of spontaneous haemorrhage.

==Clinical Significance==

==Clinical Significance==