Changes

{{review}}

{{review}}

==Introduction==

|linkpage =WikiDrugs

|linktext =WikiDrugs

|sublink1 = Anthelmintic Drugs

|subtext1 = Anthelmintic Drugs

 

This group of drugs are derived from ''Streptomyces'' species and are coded as '''3-AV''' products. They are commonly known as '''avermectins''' and '''milbemycins'''. Drugs in use include; '''ivermectin, abamectin, doramectin, moxidectin, eprinomectin''' and '''selamectin'''.  

This group of drugs are derived from ''Streptomyces'' species and are coded as '''3-AV''' products. They are commonly known as '''avermectins''' and '''milbemycins'''. Drugs in use include; '''ivermectin, abamectin, doramectin, moxidectin, eprinomectin''' and '''selamectin'''.  

==Pharmacokinetics==

==Pharmacokinetics==

* These drugs are excreted very slowly and so the plasma concentration curve has a very long tail.

* These drugs are excreted very slowly and so the plasma concentration curve has a very long tail.

* The initial peak will kill all adult worms and the residual "tail" is able to have a high enough concentration to ensure that infective larvae ingested, for a time after treatment, are incapable of establishing. This provides a '''period of protection against reinfection'''.

* The initial peak will kill all adult worms and the residual "tail" is able to have a high enough concentration to ensure that infective larvae ingested, for a time after treatment, are incapable of establishing. This provides a '''period of protection against reinfection'''.