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==Introduction==

==Introduction==

[[Image:SSC-like lesion donkey.jpg|right|thumb|200px|<small><center>Squamous cell carcinoma-like lesion. This resolved with potassium iodide therapy suggesting that it was in fact a pyogranuloma.(Image courtesy of  [http://drupal.thedonkeysanctuary.org.uk The Donkey Sanctuary])</center></small>]]

[[Image:SSC-like lesion donkey.jpg|right|thumb|200px|<small><center>Squamous cell carcinoma-like lesion. This resolved with potassium iodide therapy suggesting that it was in fact a pyogranuloma.(Image courtesy of  [http://drupal.thedonkeysanctuary.org.uk The Donkey Sanctuary])</center></small>]]

Squamous cell carcinoma (SCC) is one of the common neoplasms affecting the eyelids and the third eyelid.  

Squamous cell carcinoma (SCC) is one of the common neoplasms affecting the eyelids and the third eyelid. It occurs in donkeys in much the same way and character as in horses, although there may be less correlation with non-pigmented skin. It is likely that the prevalence is lower than in horses, but there is no firm published information. '''Cutaneous and ocular forms''' are, in D. Knottenbelt’s limited experience, '''more common than penile/vulvar forms'''. '''Ulcerative''' and '''proliferative''' (and mixed destructive-proliferative) forms do occur.

It occurs in donkeys in much the same way and character

as in horses, although there may be less correlation with non-pigmented skin. It

is likely that the prevalence is lower than in horses, but there is no firm published

information. '''Cutaneous and ocular forms''' are, in D. Knottenbelt’s limited experience,

'''more common than penile/vulvar forms'''. '''Ulcerative''' and '''proliferative''' (and

mixed destructive-proliferative) forms do occur.

==Signalment==

==Signalment==

* Diagnosis is invariably achieved by careful biopsy of a representative site.

* Diagnosis is invariably achieved by careful biopsy of a representative site.

* SCC is aggressive locally, but slow to metastasise. If associated with the orbit or eyelids, SCC carries a poor prognosis compared to cornea or conjunctival involvement. Always check for metastasis: palpate the '''regional lymph nodes and bony orbit''', '''auscultate the chest''' and '''check the rest of the body''', especially the perineal and preputial areas. About 15% are bilateral

* SCC is aggressive locally, but slow to metastasise. If associated with the orbit or eyelids, SCC carries a poor prognosis compared to cornea or conjunctival involvement. Always check for metastasis: palpate the '''regional lymph nodes and bony orbit''', '''auscultate the chest''' and '''check the rest of the body''', especially the perineal and preputial areas. About 15% are bilateral.

* Check any skin lesion around the eyelid margins that is ulcerative. Repulse the eyeball to study the '''third eyelid'''. Prompt action should be taken to investigate. '''Biopsy''' is essential for diagnosis.  

* Check any skin lesion around the eyelid margins that is ulcerative. Repulse the eyeball to study the '''third eyelid'''. Prompt action should be taken to investigate. '''Biopsy''' is essential for diagnosis.  

* Other neoplasms have been reported.  

* Other neoplasms have been reported.  

Treatment and prognosis depend on the tumour type, site and extent.

Treatment and prognosis depend on the tumour type, site and extent.

Treatment options are effectively limited to '''surgical excision''' or '''cryosurgery'''. There are no scientific comparative

Treatment options are effectively limited to '''surgical excision''' or '''cryosurgery'''. There are no scientific comparative studies on the use of cisplatin, 5-fluorouracil or radiation in donkeys and, given the paucity of literature reports, it is difficult to predict which treatments are best in any particular circumstances. Typically for all neoplastic diseases the best prognosis is likely to be achieved with aggressive treatment of small lesions.

studies on the use of cisplatin, 5-fluorouracil or radiation in donkeys and, given the paucity of literature reports, it is difficult to predict which treatments are best in any particular circumstances. Typically for all neoplastic diseases

the best prognosis is likely to be achieved with aggressive treatment of small lesions.

Prognosis should be considered before embarking on therapy. Orbital involvement carries a poor prognosis.

Prognosis should be considered before embarking on therapy. Orbital involvement carries a poor prognosis.

* Extensive tumours may require enucleation

* Extensive tumours may require enucleation.

* Surgical excision of the tumour carries a 55% recurrence rate in horses

* Surgical excision of the tumour carries a 55% recurrence rate in horses.

* Treatment may require referral and hospitalisation, as effective treatments may involve radiotherapy, cryotherapy or immunotherapy. Costs may be considerable. Specialist advice should be sought

* Treatment may require referral and hospitalisation, as effective treatments may involve radiotherapy, cryotherapy or immunotherapy. Costs may be considerable. Specialist advice should be sought.

==Prevention==

==Prevention==

It is difficult to give any advice regarding prevention, but sunlight is a potential carcinogen for nonpigmented

It is difficult to give any advice regarding prevention, but sunlight is a potential carcinogen for nonpigmented skin. Exposure to sun of the ear tips and non-pigmented eyelids or nictitans mucosa may be significant factors.

skin. Exposure to sun of the ear tips and non-pigmented eyelids or nictitans mucosa may be significant factors.

 

 

 

==References==

==References==

|linkpage =Neoplastic Skin Disorders - Donkey

|linkpage =Neoplastic Skin Disorders - Donkey

|linktext =Neoplastic Skin Disorders - Donkey

|linktext =Neoplastic Skin Disorders - Donkey

|rspace={{Donkey}}

|sublink1 =Eyelid Diseases - Donkey

|subtext1 =Eyelid Diseases - Donkey

|pagetype=Donkey

|pagetype=Donkey

}}

}}