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==Prescribing for donkeys==
==Prescribing for donkeys==
[[Image:Donkey Mexico.JPG|thumb|right|200px|<small><center>Image courtesy of [http://drupal.thedonkeysanctuary.org.uk The Donkey Sanctuary]</center></small>]]
Pharmacokinetic differences have been demonstrated between horses and donkeys for a number of drugs e.g. oxytetracycline (Horspool ''et al'', 1990), trimethoprim-sulfamethoxazole (Peck ''et al'', 2002), phenylbutazone (Mealey ''et al'', 1997, Matthews ''et al'', 2001), flunixin meglumine (Coakley ''et al'', 1999), and guaifenesin (Matthews ''et al'', 1997) with, in general, Vd being lower, CL being higher and/or t½ being shorter in donkeys than in horses. These differences are of potential clinical significance for some, but not all, drugs that undergo hepatic biotransformation (Peck ''et al'', 1997). The NSAID carprofen is apparently metabolised more slowly in donkeys than in horses (Mealey 'et al'', 2004).
Pharmacokinetic differences have been demonstrated between horses and donkeys for a number of drugs e.g. oxytetracycline (Horspool ''et al'', 1990), trimethoprim-sulfamethoxazole (Peck ''et al'', 2002), phenylbutazone (Mealey ''et al'', 1997, Matthews ''et al'', 2001), flunixin meglumine (Coakley ''et al'', 1999), and guaifenesin (Matthews ''et al'', 1997) with, in general, Vd being lower, CL being higher and/or t½ being shorter in donkeys than in horses. These differences are of potential clinical significance for some, but not all, drugs that undergo hepatic biotransformation (Peck ''et al'', 1997). The NSAID carprofen is apparently metabolised more slowly in donkeys than in horses (Mealey 'et al'', 2004).
product approved for use in the horse should be selected and used at the
product approved for use in the horse should be selected and used at the
approved dose rate and regime.
approved dose rate and regime.
==Literature Search==
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Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation).
<br><br><br>
[http://www.cabdirect.org/search.html?q=(donkey+horse)+AND+subject:(pharmacology) Pharmacology and donkeys and horses publications]
==References==
==References==
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[[Category:Pharmacology_-_Donkey]]