Changes

==The inflammatory response==

==The inflammatory response==

[[Image:Donkey picture.JPG|thumb|right|200px|<small><center>Image courtesy of [http://drupal.thedonkeysanctuary.org.uk The Donkey Sanctuary]</center></small>]]  

[[Image:Donkey picture.JPG|thumb|right|200px|<small><center>Image courtesy of [http://drupal.thedonkeysanctuary.org.uk The Donkey Sanctuary]</center></small>]]  

Nearly all [[NSAIDs]] also potentially induce hepatic injury and this should be considered, particularly when these agents are administered concomitantly with other potentially hepatotoxic agents, such as the [[Potentiated-Sulphonamides|potentiated sulphonamides]]. [[NSAIDs]] should be used with '''particular care in aged animals''', particularly with '''pre-existing renal, cardiac or hepatic disease''', and in cases that are '''dehydrated, in shock or undergoing concurrent therapy with nephrotoxic drugs'''. Particular care is also required when [[NSAIDs]] are administered concurrently with other compounds that are also '''highly protein-bound''', ''e.g.'' the [[Sulphonamides|sulphonamides]].

Nearly all [[NSAIDs]] also potentially induce hepatic injury and this should be considered, particularly when these agents are administered concomitantly with other potentially hepatotoxic agents, such as the [[Potentiated-Sulphonamides|potentiated sulphonamides]]. [[NSAIDs]] should be used with '''particular care in aged animals''', particularly with '''pre-existing renal, cardiac or hepatic disease''', and in cases that are '''dehydrated, in shock or undergoing concurrent therapy with nephrotoxic drugs'''. Particular care is also required when [[NSAIDs]] are administered concurrently with other compounds that are also '''highly protein-bound''', ''e.g.'' the [[Sulphonamides|sulphonamides]].

==References==

==References==