Line 1: |
Line 1: |
− | *amyloid infiltration occurs in all species
| + | ==Introdcution== |
− | *an inert substance deposited under the endothelium and basement membranes of a variety of tissues
| + | Amyloid infiltration occurs in all species - amaloid is an inert substance that becomes deposited under the endothelium and basement membranes of a variety of tissues, notably the renal glomeruli, |
− | **renal glomeruli
| + | [[Pancreas - Anatomy & Physiology#Endocrine|Islets of Langerhans]] in the [[Pancreas - Anatomy & Physiology|pancreas]] and the [[Liver - Anatomy & Physiology|liver]] (between the sinusoidal reticulum and the hepatic cords). |
− | **[[Pancreas - Anatomy & Physiology#Endocrine|Islets of Langerhans]] in the [[Pancreas - Anatomy & Physiology|pancreas]]
| + | |
− | **[[Liver - Anatomy & Physiology|liver]] (between the sinusoidal reticulum and the hepatic cords)
| + | ==Causes== |
− | ====Causes====
| |
| May be a primary condition or appear secondary to some chronic tissue destructive process | | May be a primary condition or appear secondary to some chronic tissue destructive process |
| *an infectious process elsewhere in the body | | *an infectious process elsewhere in the body |
| *a result of sustained antigenic stimulation, eg repeated injections with an antigenic substance or production of excessive antibody by leukocytes | | *a result of sustained antigenic stimulation, eg repeated injections with an antigenic substance or production of excessive antibody by leukocytes |
| | | |
− | ====Gross====
| + | ==Gross Pathology== |
| *pale (greyish waxy appearance) | | *pale (greyish waxy appearance) |
| *enlarged | | *enlarged |
Line 15: |
Line 14: |
| *firm | | *firm |
| *very prone to rupture | | *very prone to rupture |
| + | |
| ====Microscopically==== | | ====Microscopically==== |
| *deposition of amyloid in the space of Disse | | *deposition of amyloid in the space of Disse |
Line 20: |
Line 20: |
| | | |
| ==Arterial== | | ==Arterial== |
− |
| |
| Amyloid is an eosinophilic, homogenous, hyaline material. Due to its beta-pleated-sheet structure it is almost insoluble. Amyloid may be: | | Amyloid is an eosinophilic, homogenous, hyaline material. Due to its beta-pleated-sheet structure it is almost insoluble. Amyloid may be: |
| *'''AA''': Serum amyloid A, alpha-2 globulin. | | *'''AA''': Serum amyloid A, alpha-2 globulin. |