|
|
(2 intermediate revisions by the same user not shown) |
Line 1: |
Line 1: |
− | {{review}}
| + | #REDIRECT[[:Category:Integumentary System - Immunologic Pathology]] |
− | | |
− | {{toplink
| |
− | |backcolour = FFCCCC
| |
− | |linkpage =Integumentary System - Pathology
| |
− | |linktext =Integumentary System
| |
− | |maplink = Integumentary System (Content Map) - Pathology
| |
− | |pagetype =Pathology
| |
− | }}
| |
− | <br>
| |
− | | |
− | ==General==
| |
− | | |
− | *Classification:
| |
− | **Hypersensitivity - response to normally harmless substances
| |
− | **Auto-immune - antobodies or T-cells reactive against self-antigens
| |
− | *Mostly involves mixture of types described below
| |
− | | |
− | | |
− | | |
− | ==Autoimmune reactions==
| |
− | | |
− | ===[[Bullous Pemphigoid]]===
| |
− | | |
− | | |
− | | |
− | ===[[Canine Dermatomyositis]]===
| |
− | | |
− | | |
− | ===[[Systemic Lupus Erythematosus]]===
| |
− | | |
− | *'''Systemic (SLE)'''
| |
− | **Multiple organs involved
| |
− | **Cats, dogs, horses
| |
− | **Immune dysregulation:
| |
− | ***Damaged T-cell suppressor function, either primary deficiency or antibody mediated
| |
− | ***Cytokine dysregulation
| |
− | ***Resulting B-cell hyperactivity -> antibodies to self antigens -> antigen-antibody complexes deposited in various tissues -> Type III hypersensitivity
| |
− | **Lesions localised or generalised
| |
− | **Erythema, alopecia, depigmentation, crusting and scaling, ulceration
| |
− | **Microscopically: lymphohistiocytic interface dermatitis, thickened basement membrane, vasculitis, subepidermal vesicles, basal cell degeneration
| |
− | *'''Discoid'''
| |
− | **Milder variant of systemic
| |
− | **Depigmentation, erythema, scaling, erosions, ulceration, crusting
| |
− | **Usually involves nasal planum, dorsum of muzzle, occasionally pinnae, lips, oral mucosa or periocular area
| |
− | **Microscopically: lichenoid interface dermatitis, often with lymphocytes, plasma cells, basal cell degeneration, loss of pigment
| |
− | | |
− | [[Category:Integumentary System - Autoimmune Reactions]]
| |
− | | |
− | ===[[Pemphigus]]===
| |