Difference between revisions of "Testicular Feminisation"

Latest revision as of 23:06, 26 October 2011

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-'''''Aetiology'''''
+#redirect[[Intersex#Testicular feminisation]]
-* Genotype XY as should be in the male.
-* Testes develop normally and secrete Androgens and MIH
-* Foetal genetalia are genetically insensitive to the actions of Androgens due to a point mutation in the Androgen receptor.
-'''''Consequence'''''
-* Wolffian Ducts regress, allowing formation of '''female external genetalia''':
-** Labia
-** Clitoris
-** Vagina
-* Sertoli cells are present and continue to secrete MIH, causing Mullarian Duct regression.
-* Since both Wolffian AND Mullarian Ducts regress, there is '''no internal genetalia'''.