Difference between revisions of "Adrenogenital Syndrome"

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'''''Aetiology'''''
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== Aetiology ==
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* Genotype is XX as should be female
 
* Genotype is XX as should be female
 
* Ovaries develop normally
 
* Ovaries develop normally
* Foetal [[Endocrine_System_-_Adrenal_Glands_-_Anatomy_%26_Physiology|Adrenal Gland]] is hyperactive and secretes large quantities of Adrenal Androgens, due to a '''21 hydroxylase mutation'''.
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* Foetal [[Adrenal_Glands_- Anatomy & Physiology|Adrenal Gland]] is hyperactive and secretes large quantities of Adrenal Androgens, due to a '''21 hydroxylase mutation'''.
  
  
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== Consequence ==
  
'''''Consequence'''''
 
  
 
* Wolffian Ducts persist due to the presence of Androgens, thus allowing development of '''male internal and external genitalia'''.
 
* Wolffian Ducts persist due to the presence of Androgens, thus allowing development of '''male internal and external genitalia'''.
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== Morphology ==
  
'''''Morphology'''''
 
  
 
* Appears male with a '''micropenis and scrotum'''
 
* Appears male with a '''micropenis and scrotum'''
 
* Both male and female internal genitalia
 
* Both male and female internal genitalia
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[[Category:Reproductive Disorders]]
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[[Category:Reproductive Diseases - Dog]][[Category:Reproductive Diseases - Cat]]

Latest revision as of 14:25, 23 December 2010

Aetiology

  • Genotype is XX as should be female
  • Ovaries develop normally
  • Foetal Adrenal Gland is hyperactive and secretes large quantities of Adrenal Androgens, due to a 21 hydroxylase mutation.


Consequence

  • Wolffian Ducts persist due to the presence of Androgens, thus allowing development of male internal and external genitalia.
  • Mullarian Ducts persist due to the absence of testes, hence absence of Sertoli cell MIH secretion. This allows formation of female internal genitalia.


Morphology

  • Appears male with a micropenis and scrotum
  • Both male and female internal genitalia