|
|
| (12 intermediate revisions by 3 users not shown) |
| Line 1: |
Line 1: |
| − | <big><center>[[Viruses|'''BACK TO VIRUSES''']]</center></big>
| + | #REDIRECT[[:Category:Herpesviridae]] |
| − | | |
| − | | |
| − | ==Introduction==
| |
| − | | |
| − | *Equine herpes virus 1 and 4 in [[Nasal Cavity Inflammatory - Pathology#Infectious causes of rhinitis|rhinitis]], see [[Respiratory Viral Infections - Pathology#Equine rhinopneumonitis|respiratory infections]]
| |
| − | *Canine herpes virus 1 in [[Respiratory Viral Infections - Pathology#Canine herpes virus|respiratory disease]]
| |
| − | | |
| − | *In [[Viral skin infections - Pathology#Herpesviruses|skin infections]]
| |
| − | **Bovine herpes virus 1, 2 4
| |
| − | **Equine herpes virus 3
| |
| − | **Feline herpes virus 1
| |
| − | | |
| − | ===Feline herpesvirus -1===
| |
| − | | |
| − | *Feline viral rhinotracheitis in [[Nasal Cavity Inflammatory - Pathology#Infectious causes of rhinitis|rhinitis]], see [[Respiratory Viral Infections - Pathology#Feline viral rhinotracheitis|respiratory infections]]
| |
| − | **One of the causes of Feline viral rhinotracheitis
| |
| − | ***Viruses and bacteria are involved in the complex. The most frequent aetiologic agent is FHV-1, and less frequently feline calicivirus and/or [[Chlamydia and Chlamydophila species|''Chlamydophia psittaci'']] (NB: previously called Chlamydia psittaci var felis)
| |
| − | ***All three agents infect URT respiratory epithelium, although FHV-1 has the highest affinity for this epithelium
| |
| − | ***Feline calicivirus more frequently infects the oral mucosa -> ulcerative stomatitis
| |
| − | ***C.psittaci more frequently infects the conjunctival epithelium -> chronic conjunctivitis
| |
| − | ***Infection of the respiratory epithelium by FHV-1 results in a typical neutrophilic rhinitis with intraepitheial intranuclear eosinophilic inclusion bodies, with expected clinical signs
| |
| − | ***Resolution of clinical signs usually occurs by 7-14 days.
| |
| − | ***FHV-1 remains latent in the trigeminal ganglion, and can reactivate at times of stress. Can infect the cornea -> ulcerative keratitis.
| |
| − | ***Occasional mortality in kitten or immunocompromised animals usually associated with secondary bacterial infection.
| |
| − | | |
| − | | |
| − | ===Bovine herpesvirus -1===
| |
| − | * Bovine herpesvirus - 1 (Infectious bovine rhinotracheitis virus) contributes to [[Intestines - Catarrhal Enteritis#Undifferentiated Neonatal Calf Diarrhoea|undifferentiated neonatal calf diarrhoea]], a mixed viral enteritis in calves; and [[Nasal Cavity Inflammatory - Pathology#Infectious causes of rhinitis|rhinitis]]
| |
| − | *Causes [[Respiratory Viral Infections - Pathology#Infectious bovine rhinotracheitis (IBR)|'''Infectious bovine rhinotracheitis (IBR)''']]
| |
| − | *Highly infectious URT disease of cattle
| |
| − | *High morbidity, low mortality
| |
| − | *Aerosol transmission - requires close contact between animals
| |
| − | *BHV-1 infects the respiratory mucosal epithelial cells (intranuclear inclusion eosinophilic inclusion bodies)from nasal mucosa down to bronchioles
| |
| − | **leading to neutrophilic inflammation of varying severity.... serous -> catarrhal -> purulent nasal discharge, sneezing, coughing.
| |
| − | **with secondary bacterial infection (eg: Pasturella spp., Mycoplasma spp., Fusobacterium necrophorum) can lead to fibrinous to necrotizing inflammation; mucosal sloughing, ulceration... pyrexia, dyspnoea ... inhalation pneumonia... death.
| |
| − | *Clinical signs include coughing, discharge, lacrimation, and increased respiratory rate.
| |
| − | *Clinical disease most severe in young calves - can develop mucosal ulcerative lesions in the oesophagus and forestomachs and viraemia with multiorgan infection.
| |
| − | *Cause of abortion >5 months of gestation
| |
| − | | |
| − | *Also causes infectious vulvovaginitis/balanoposthitis and meningoencephalitis
| |
| − | *May contribute to [[Respiratory Bacterial Infections - Pathology#Enzootic pneumonia of calves|Enzootic pneumonia of calves]]
| |
| − | | |
| − | ===Inclusion body rhinitis (porcine cytomegalovirus)===
| |
| − | *in [[Nasal Cavity Inflammatory - Pathology#Infectious causes of rhinitis|rhinitis]] and sometimes in [[Respiratory Bacterial Infections - Pathology#In Pigs|atrophic rhinitis]] progressing to [[Lungs - inflammatory#Infectious causes of pneumonia|pneumonia]], see [[Respiratory Viral Infections - Pathology#Inclusion body rhinitis|Inclusion body rhinitis]]
| |
| − | | |
| − | *Cytomegaloviruses
| |
| − | **Porcine cytomegalovirus
| |
| − | ***Causes Inclusion body rhinitis
| |
| − | ****Disease of suckling piglets 1-5 wks of age
| |
| − | ****Clinical signs: those associated with acute/subacute rhinitis (ie: serous nasal discharge, progressing to catarrhal or purulent discharge with time and secondary bacterial infections; sneezing; pyrexia)
| |
| − | ****Morbitity high, mortality low
| |
| − | ****Histology: large basophilic intranuclear inclusion bodies in the nasal and sinus respiratory epithelium with lymphocytic infiltration of the mucosa.
| |
| − | ****Can develop viraemic stage, with inclusions in other organs eg: renal tubular epithelium. Piglets can die during this phase.
| |
| − | | |
| − | ==Alphaherpesviridae==
| |
| − | ==Betaherpesviridae==
| |
| − | ==Gammaherpesviridae==
| |
| − | [[Oral Cavity - Cavity & Gingiva#Malignant Catarrhal Fever|Alcephaline-1 Virus]]
| |