Difference between revisions of "Joint Response to Injury"
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===Causes of injury === | ===Causes of injury === | ||
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***Non-painful | ***Non-painful | ||
**Defects reaching subchondral bone | **Defects reaching subchondral bone | ||
| − | ***Filled with vascular fibroous tissue undergoing [[ | + | ***Filled with vascular fibroous tissue undergoing [[Cell Growth Disorders#Metaplasia|metaplasia]] into cartilage |
***Painful | ***Painful | ||
**Fibrillation - loss of proteoglycans -> condensation of collagen fibres -> fraying of surface | **Fibrillation - loss of proteoglycans -> condensation of collagen fibres -> fraying of surface | ||
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*Synovial membranes respond by: | *Synovial membranes respond by: | ||
**Villous hypertrophy | **Villous hypertrophy | ||
| − | ***+/- | + | ***+/- synovitis |
**Hyperplasia | **Hyperplasia | ||
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| + | [[Category:Joints - Pathology|A]] | ||
Latest revision as of 16:43, 3 March 2011
Causes of injury
- Trauma
- Instability
- Lubrication failure
- Infectious organisms
- Immune-mediated disease
Reaction to injury
- Articular cartilage has limited ability to regenerate
- Superficial defects are long standing
- Chondrocyte hyperplasia is ineffective at filling the defect
- Non-painful
- Defects reaching subchondral bone
- Filled with vascular fibroous tissue undergoing metaplasia into cartilage
- Painful
- Fibrillation - loss of proteoglycans -> condensation of collagen fibres -> fraying of surface
- Eburnation - loss of articular cartilage -> exposure of subchondral bone -> becomes dense and polished
- Superficial defects are long standing
- Synovial membranes respond by:
- Villous hypertrophy
- +/- synovitis
- Hyperplasia
- Villous hypertrophy