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− | {{unfinished}}
| + | #REDIRECT[[:Category:Integumentary System - Pathology]] |
− | {{toplink
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− | |backcolour = FFCCCC
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− | |linkpage =Integumentary System - Pathology
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− | |linktext =Integumentary System
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− | |maplink = Integumentary System (Content Map) - Pathology
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− | |pagetype =Pathology
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− | }}
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− | <br>
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− | ==Epidermal growth or differentiation disorders==
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− | ===Seborrheic disease complex===
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− | *Abnormal cornification or function of sebaceous glands
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− | *Large amounts of free fatty acids and cholesterol
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− | *Decreased amounts of diester waxes in surface lipids
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− | *Bacterial population changes to pathogenic [[Staphylococcus spp.|coagulase positive staphylococci]]
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− | *Chronic disease affecting mainly dogs, sometimes cats and horses
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− | *Dry form - white to grey scales
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− | *Greasy form - scaly, excess brown to yellow lipids sticking to skin and hair
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− | ===Primary idiopathic seborrhea===
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− | *Abnormal cornification
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− | *Epidermal turnover reduced to about 2/3 of normal
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− | *Microscopically:
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− | **Hyperkeratosis distending follicular ostia causing papillary appearance
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− | **Parakeratosis at edges of follicular ostia
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− | **Congested, oedematous dermal papillae
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− | **Spongiotic epidermis with leukocytes
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− | ===Secondary seborrhea===
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− | *Develops secondarily to many types of disease (''e.g.'' [[Parasitic skin infections - Pathology|ectoparasites]], [[Mycotic skin infections - Pathology|fungal infections]], [[Endocrine effects on the skin - Pathology|endocrine disease]], internal disease or allergy)
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− | *Microscopically:
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− | **Hyperkeratosis and/or parakeratosis of follicles and epidermis
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− | **Lesions relevant to the other disease
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− | ===Sebaceous adenitis===
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− | *Inflammation of sebaceous glands, alopecia, hyperkeratosis
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− | *Possibly immune-mediated
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− | *Mainly affects dogs
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− | **Long haired show multifocal, serpiginous and annular lesions
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− | *Microscopically:
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− | **Inflammation of sebaceous glands
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− | **Possibly orthokeratotic hyperkeratosis
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− | **Chronic lesions are deprived of sebaceous glands and contain mild inflammation and fibrosis at follicular isthmus
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− | ==Pigmentation disorders==
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− | ===Hypopigmentation===
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− | ===Hyperpigmentation===
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− | ==Eosinophilic infiltration==
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− | ===Eosinophilic plaques===
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− | ===Eosinophilic granulomas===
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− | ===Eosinophilic folliculitis and furunculosis===
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− | ==Sterile granulomatous disorders==
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− | ===Juvenile pyoderma===
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− | ===Equine generalised granulomatous disease===
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